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Vashishtiputra Sātakarni was a Satavahana king, who ruled the Deccan region in India, during the 2nd century CE. He was the brother of Vasisthiputra Sri Pulamavi, his regnal successor, and the son of the great Satavahana conqueror Gautamiputra Satakarni. His reign is dated variously: 138-145 CE, or 158-165 CE.
Vashishtiputra Sātakarni was in great conflict with the Scythian Western Kshatrapas in the West, but he eventually married the daughter of Rudradaman I of the Western Kshatrapa dynasty, in order to forge an alliance. Later however, he was defeated by his father-in-law in battle, with serious effect on Sātavāhana power and prestige:
"Rudradaman (...) who obtained good report because he, in spite of having twice in fair fight completely defeated Satakarni, the lord of Dakshinapatha, on account of the nearness of their connection did not destroy him."