Quick Facts
Biography
Dipyaman Ganguly is an Indian immunologist and cell biologist, currently a Principal Scientist and Swarnajayanthi Fellow at the CSIR-Indian Institute of Chemical Biology (IICB). He heads the Dendritic Cell Laboratory of IICB, popularly known as Ganguly Lab, where he hosts several researchers involved in research on regulation of innate Immunity and pathogenesis of inflammatory disorders.
Ganguly graduated in medicine from Medical College and Hospital, Kolkata in 2001 but shifted his focus to biomedical research and joined the Institute of Genomics and Integrative Biology as a clinical associate. In 2003, he joined Indian Institute of Chemical Biology for doctoral research as a research scholar which earned him his first PhD in 2006. Moving to the USA, he carried on his research at University of Texas MD Anderson Cancer Center and received another PhD from the University of Texas Health Science Center at Houston. His post-doctoral work was at the Columbia University Medical Center as an SLE Foundation Fellow and on his return to India, he joined IICB where he is a currently a Senior Scientist. He is also a Swarnajayanthi Fellow of the Department of Science and Technology, andwas formerly a Ramanujan Fellow of the Science and Engineering Research Board of the Department of Science and Technology.
The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2017/18. He is also a recipient of the CDRI Award for Excellence in Drug Research from CSIR-Central Drug Research Institute, Swarnajayanthi Fellowship of the Department of Science and Technology and the NASI-Scopus Young Scientist Award of the Elsevier.
Scientific contribution
Research interests of Ganguly lab are exploring the role of dendritic cells in autoreactive inflammatory contexts, deciphering molecular regulation of innate immune response and exploring the role of mechanical cues in immune cells. Researchers from Ganguly Lab recently discovered a novel regulatory module involving the Piezo1 mechanosensors in human T cells, driven by mechanical cues. They also provided the first evidence for involvement of plasmacytoid dendritic cells in obesity and associated metabolic syndrome in humans. Previous work by Dipyaman Ganguly led to discovery of the key initiation events in pathogenesis of the skin autoimmunity in Psoriasis, as well as first identification of dying neutrophils as the major source of nuclear antigens in systemic lupus, which was featured in Nature Reviews Key Advances in Medicine for the year 2012. Ganguly lab has also interest in development of new therapies for autoimmune diseases.
Selected bibliography
- Sisirak V, Ganguly D, Lewis KL, Couillault C, Tanaka L, Bolland S, D'Agati V, Elkon KB, Reizis B (September 2014). "Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus". The Journal of Experimental Medicine. 211 (10): 1969–76. doi:10.1084/jem.20132522. PMC 4172218. PMID 25180061.
- Lande R, Ganguly D, Facchinetti V, Frasca L, Conrad C, Gregorio J, Meller S, Chamilos G, Sebasigari R, Riccieri V, Bassett R, Amuro H, Fukuhara S, Ito T, Liu YJ, Gilliet M (March 2011). "Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus". Science Translational Medicine. 3 (73): 73ra19. doi:10.1126/scitranslmed.3001180. PMC 3399524. PMID 21389263.
- Nargis T, Kumar K, Ghosh AR, Sharma A, Rudra D, Sen D, Chakrabarti S, Mukhopadhyay S, Ganguly D, Chakrabarti P (November 2017). "KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes". Molecular Metabolism. 6 (11): 1529–1539. doi:10.1016/j.molmet.2017.09.004. PMC 5681279. PMID 29107298.
- Roy S, Mukherjee A, Paul B, Rahaman O, Roy S, Maithri G, Ramya B, Pal S, Ganguly D, Talukdar A (July 2017). "Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism". European Journal of Medicinal Chemistry. 134: 334–347. doi:10.1016/j.ejmech.2017.03.086. PMID 28437629.
Public outreach
Ganguly is an enthusiast for public outreach of science in India. He serves as the convener of the Rural Scientific Outreach Initiative of Center for Observational Astronomy, Kolkata, a non-profit society for public outreach of science. Ganguly spends his free time in delivering public talks. He is also takes interest in amateur astronomy and is involved in arranging for skywatching events for school-going kids in the city as well as in remote rural areas.
