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Chloe Aurelia Clark Willson (1818–1874) was an early pioneer of what became the U.S. state of Oregon, and one of the first teachers of the Methodist mission in the Willamette Valley.
Chloe Clark (sometimes Clarke) was born on April 16, 1818, in East Windsor, Connecticut. She was educated at the Wilbraham Academy.
She married William H. Willson, later the founder of Salem, Oregon, on August 16, 1840, at the Nisqually Mission. It was the first wedding of American citizens in western Washington.
Willson became the first teacher of the Oregon Institute, which was founded after the failure of the Methodist mission. Willson may be best known for her diary, which chronicled her journey to Oregon on the ship Lausanne and her life as a missionary teacher, as well as her later life, and is a valuable resource for historians. In 1935, the diary was donated to Willamette University (the successor to the Oregon Institute) by her son-in-law Joseph K. Gill.