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Don Carlos Manuel O'Donnell y Álvarez de Abreu, 2nd Duke of Tetuan Grandee of Spain, 9th Marquis of Altamira and 2nd Count of Lucena (Valencia, 1 June 1834 – Madrid, 9 February 1903) was a Spanish noble and politician who served four times as Minister of State, the name which then received the Spanish Foreign Minister. He was also Mayordomo mayor to King Amadeo I.
The Duke was son of Carlos María O'Donnell y Joris, eldest brother of General Leopoldo O'Donnell, 1st Duke of Tetuan (several times Prime Minister of Spain), and Maria del Mar Álvarez de Abreu y Rodríguez de Albuerne, 8th Marquesa of Altamira and the granddaughter of Don Manuel Rodriguez de Albuerne y Pérez de Tagle, 5th Marquis of Altamira. In 1867 after his uncle's death, he inherited all his title and fortune.