Sir William Skipwith (by 1487-7 July 1547), was an English politician.
He was the eldest son of Sir John Skipwith (Born 1441) of South Ormsby, and his wife Katherine (Born 1450). he succeeded his father in 1518 and was knighted in 1533 or 1534.
He was a Member (MP) of the Parliament of England for Lincolnshire in 1529 and 1539.
He was a Justice of the Peace (JP) for Lindsey from 1520 to his death and appointed High sheriff of Lincolnshire for 1526–27.
He married twice: firstly Elizabeth, the daughter of Sir William Tyrwhitt of Kettleby, Lincolnshire with whom he had a son ; and secondly Alice, the daughter and coheiress of Sir Lionel Dymoke of Mareham-on-thy-Hill, Lincolnshire, with whom he had a further four sons and seven daughters. He was succeeded by his son and heir Sir William.