Teotlalco (Nahuatl pronunciation: THEO-LAL-COH) was a Nahua princess of Ecatepec and Aztec empress—the Queen of Tenochtitlan.
Teotlalco's father was King Matlaccohuatl. She married Emperor Moctezuma II of Tenochtitlan. The first contact between Indigenous civilizations of Mesoamerica and Europeans took place during his reign, and he was killed. Teotlalco was Moctezuma's principal wife and mother of Doña Isabel Moctezuma, wife of the king Cuitláhuac. Her grandchild was Leonor Cortés Moctezuma.