Stratonice of Pontus (Greek: Στρατoνίκη; fl. 1st century BC) was a Greek woman from the Kingdom of Pontus who one of the mistresses and the fourth wife of King Mithridates VI of Pontus.
Stratonice was a citizen of the Pontian city of Kabeira. She was originally a woman of mean birth and was the daughter of a Harpist.
Stratonice was a harpist in the court of Mithridates VI. She became one of the mistresses to the King and eventually Mithridates VI married her as one of his wives after 86 BC. Stratonice bore Mithridates, a son called Xiphares. Stratonice became one of the favorite wives of the King and had obtained much influence over him. When Mithridates VI was compelled to undertake his perilous retreat to the Black Sea, Mithridates VI left Stratonice in charge of a strong fortress, at Coenum in which he had deposited a large amount of treasure.
Stratonice was induced to betray both the fortress and the fortress’ treasures into the hands of the Roman General Pompey, on the condition that Pompey should spare the life of her son. However Mithridates VI punished her for her treason by putting their son to death before her eyes. She died by 63 BC, when the Kingdom of Pontus was annexed by the Roman General Pompey.