Spytek of Melsztyn (Polish: Spytek z Melsztyna or Spytko Melsztyński) was a Polish nobleman (szlachcic).
Spytek was owner of Melsztyn estates. He served as Court Marshal since 1373, voivode of Kraków Voivodeship since 1381, starosta of Biec since 1383 and Kraków since 1390.
He initiated the marriage of Queen Jadwiga of Poland and Grand Duke of Lithuania - to become king of Poland - Władysław II Jagiełło. In 1391–1396 Spytek reclaimed the Land of Wieluń and Orzeszków from Prince Władysław Opolczyk. In June 13, 1395 the King gave Spytek a part of Podolia as fief, Queen Jadwiga confirmed this in July 10, 1395. During the brief period when he was Duke of Podolia, he succeeded lead to the resignation Fyodor Koriatovych of the rights to Podolia and with Queen and King negotiated with the Hungarian Sigismund the border issue; and with the Bishop of Vilnius tried to prevent the secession of Lithuania from Polish–Lithuanian union, after acclamation by Vytautas the King of Lithuania in October 12, 1398. As Duke of Podolia also took part in the expedition against the Golden Horde, which ended the Battle of the Vorskla River.
He was married to Elizabeth Lackovic and had four children: Jadwiga of Melsztyn, Dorota of Melsztyn, Katarzyna of Melsztyn and Spytek of Melsztyn and Jan of Melsztyn († 1429).
Spytek died in fight with Tatars in the Battle of the Vorskla River. In the battle he had to show courage when the Lithuanian army, under the command of Vytautas, escaped.