Aged 16, she made her debut for the senior Netherlands women's national football team on 14 December 2008 in a friendly match 2–0 win over France. She was part of the Dutch squad in the UEFA Women's Euro 2009 and the 2015 FIFA Women's World Cup.
In June 2017, she was in the 23 players squad which won the UEFA Women's Euro 2017. Later that year, she was shortlisted for the UEFA Women's Player of the Year Award.
Van de Sanden was selected in the final squad for the 2019 FIFA Women’s World Cup in France.
- Scores and results list the Netherlands goal tally first.
|1.||12 March 2009||GSP Stadium, Nicosia, Cyprus||South Africa||4–0||5–0||2009 Cyprus Cup|
|2.||13 July 2009||Olympic Stadium, Amsterdam, Netherlands||South Africa||3–2||3–2||Four Nations Cup|
|3.||20 May 2015||Sparta Stadion, Rotterdam, Netherlands||Estonia||5–0||7–0||Friendly|
|4.||22 January 2016||Limak Arcadia Atlantis Football Center, Belek, Turkey||Denmark||2–0||2–0||Friendly|
|5.||2 March 2016||Kyocera Stadion, The Hague, Netherlands||Switzerland||4–1||4–3||2016 UEFA Women's Olympic Qualifying Tournament|
|6.||7 April 2016||Telstar Stadium, Velsen-Zuid, Netherlands||New Zealand||1–0||2–0||Friendly|
|8.||17 September 2016||Georgia Dome, Atlanta, United States||United States||1–0||1–3||Friendly|
|9.||20 October 2016||Tony Macaroni Arena, Livingston, Scotland||Scotland||6–0||7–0||Friendly|
|10.||16 July 2017||Stadion Galgenwaard, Utrecht, Netherlands||Norway||1–0||1–0||UEFA Women's Euro 2017|
|11.||28 February 2018||Bela Vista Municipal Stadium, Parchal, Portugal||Japan||4–0||6–2||2018 Algarve Cup|
|12.||6 April 2018||Philips Stadion, Eindhoven, Netherlands||Northern Ireland||5–0||7–0||2019 FIFA Women's World Cup qualification|
|13.||8 June 2018||Shamrock Park, Portadown, Northern Ireland||Northern Ireland||3–0||5–0||2019 FIFA Women's World Cup qualification|
|14.||5 September 2018||Rat Verlegh Stadion, Breda, Netherlands||Denmark||2–0||2–0||2019 FIFA World Cup qualifier – Play-off SF|
- FC Utrecht
- KNVB Women's Cup (1): 2009–10
- FC Twente
- BeNe League (2): 2012–13, 2013–14
- Eredivisie (4): 2012–13*, 2013–14*, 2014–15*, 2015–16
- KNVB Women's Cup (1): 2014–15
We Play Strong
Van de Sanden is one of UEFA's official ambassadors for #WePlayStrong, a social media and vlogging campaign which was launched in 2018. The campaign's "...aim is to promote women’s football as much as we can and to make people aware of women’s football, really,” Evans, another participant explains. “The ultimate goal is to make football the most played sport by females by 2020. So it’s a UEFA initiative to get more women and girls playing football, whether they want to be professional or not.” The series, which also originally included professional footballers Sarah Zadrazil, Eunice Beckmann, Laura Feiersinger and Lisa Evans and now also includes Petronella Ekroth and Shanice van de Sanden, follows the daily lives of female professional footballers.