Nicolás Amodio (born 10 March 1983) is an Uruguayan football midfielder who currently plays for Italian club Lecce.
Amodio started his football career at hometown club Defensor Sporting in Uruguay during 2003, Sporting were playing in Primera División Uruguaya at the time, which is the nation's top league. He appeared for the club only twice, before relocating to Italy.
The first Italian club he played for was Sambenedettese in Serie C, he notched up 30 appearances scoring 1 goal during his only season for the club. He would move next to Napoli along with fellow Uruguayan midfielder, Mariano Bogliacino.
Amodio was a prominent member for the club during the 2005–06 season, he turned out for them 29 times. Napoli gained promotion back to Serie B by the end of the season. In January 2010 Napoli loaned the Uruguayan midfielder to Serie B club Piacenza Calcio until June 2010.
On August 2013 he signs a contract with US Lecce.