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Napoleone Ferrara

Napoleone Ferrara

Italian molecular biologist
Napoleone Ferrara
The basics

Quick Facts

Intro Italian molecular biologist
Is Scientist Biologist Physician Molecular biologist
From United States of America
Type Biology Healthcare Science
Gender male
Birth 26 July 1956, Catania, Italy
Age 64 years
Star sign Leo
University of Catania
University of California, San Francisco
Lasker-DeBakey Clinical Medical Research Award 2010
Breakthrough Prize in Life Sciences 2013
Gairdner Foundation International Award 2014
Scientific Grand Prize of the Lefoulon-Delalande Fondation 2005
Dr. Paul Janssen Award for Biomedical Research 2011
Champalimaud Vision Award 2014
The details


Napoleone Ferrara (born 26 July 1956, Catania), is an Italian-American molecular biologist who joined University of California, San Diego Moores Cancer Center in 2013 after a career in Northern California at the biotechnology giant Genentech, where he pioneered the development of new treatments for angiogenic diseases such as cancer, age-related macular degeneration (AMD), and diabetic retinopathy. At Genentech, he discovered VEGF—and made the first anti-VEGF antibody—which suppresses growth of a variety of tumors. These findings helped lead to development of the first clinically available angiogenesis inhibitor, bevacizumab (Avastin), which prevents the growth of new blood vessels into a solid tumor and which has become part of standard treatment for a variety of cancers. Ferrara's work led also to the development of ranibizumab (Lucentis), a drug that is highly effective at preventing vision loss in intraocular neovascular disorders.


Ferrara received his medical degree from the University of Catania, Italy, in 1981, and joined Genentech in 1988. He did his postdoctoral research at University of California, San Francisco.

Current research

At UC San Diego Moores Cancer Center, Ferrara, a member of the National Academy of Sciences since 2006, serves as Senior Deputy Director for Basic Science and is a Distinguished Professor of Pathology in the UC San Diego School of Medicine, where he will continue cancer drug research targeting angiogenesis. He is presently focusing on investigating mechanisms of tumor angiogenesis alternative to VEGF, in particular the role of factors produced by myeloid cells and fibroblasts in mediating resistance to VEGF inhibitors.

Selected honors and awards

For his VEGF discovery, he won a Lasker Award in 2010. In 2013, he was awarded the $3 million Breakthrough Prize in Life Sciences for his work. He has received numerous other awards, including the General Motors Cancer Research Award (2006), the ASCO Science of Oncology Award (2007), the Pezcoller Foundation/AACR International Award (2009), the Dr. Paul Janssen Award for Biomedical Research (2011), and The Economist's Innovation Award for bioscience in 2012. Grand Prix scientifique de la Fondation Lefoulon-Delalande in 2005.

In September 2014, Ferrara was awarded the António Champalimaud Vision Award, awarded by the Champalimaud Foundation.

The contents of this page are sourced from Wikipedia article on 19 Apr 2020. The contents are available under the CC BY-SA 4.0 license.
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