Mark Emil D'Onofrio (born March 17, 1969), is an American college football coach and former professional player. He is currently the defensive coordinator and inside linebackers coach for the University of Houston. D'Onofrio played collegiately as a linebacker at Pennsylvania State University and thereafter was drafted by the Green Bay Packers of the National Football League (NFLe).
D'Onofrio played at the collegiate level with the Penn State Nittany Lions, where he was a team captain. In the 1992 NFL Draft, D'Onofrio was selected in the second round by the Green Bay Packers. He became a starter with the team that season, however a severe injury would cause him to retire soon after.
D'Onofrio's first coaching experience was as linebackers Coach at Saint Peter's College. The next year he became a defensive assistant with the Georgia Bulldogs. From there he was a linebackers coach with the Rutgers Scarlet Knights and tight ends, special teams, and inside linebackers coach with the Virginia Cavaliers. He joined the Temple Owls in 2006 as a defensive coordinator, later being promoted to the Assistant Head Coach/ Defensive Coordinator.
He followed head coach Al Golden to the University of Miami in the same position he held at Temple for the Miami Hurricanes football team in December 2010. Al Golden came to Coral Gables to replace Randy Shannon. After Golden was fired in the wake of a 58-0 loss to Clemson, D'Onofrio finished out the 2015 season as defensive coordinator and was then terminated following Miami's SunBowl loss to Washington State, 20-16.
On January 6, 2017, D'Onofrio was hired by the Houston Cougars as their defensive coordinator and inside linebackers coach, beginning with the 2017 season.