|Birth||11 March 1656, Darmstadt, Germany|
|Death||16 August 1715, Römhild, Germany (aged 59 years)|
Marie Elisabeth of Hesse-Darmstadt (11 March 1656, Darmstadt – 16 August 1715, Römhild) was the only Duchess by marriage of Saxe-Römhild.
Marie Elizabeth was a daughter of Count Louis VI of Hesse-Darmstadt (1630–1678) from his marriage to Maria Elisabeth of Holstein-Gottorp (1634–1665), a daughter of Duke Frederick III of Holstein-Gottorp.
On 1 March 1676 in Darmstadt, she married Henry, who at the time of the marriage ruled Saxe-Gotha jointly with his six brothers. In 1680, they divided the country and Henry became the Duke of Saxe-Römhild. He had resided there since 1676, in Glücksburg Castle in Römhild. After Henry's death, a dispute erupted among his remaining brothers over the inheritance of Saxe-Römhild. This dispute was settled definitively in 1765.
Henry loved his wife very much. He always called her "Marielies", and had several luxurious buildings built in her honor, including a cave house called "Marie Elisabeth Delight". They had no children. Henry died in 1710, leaving a massive debt. Marie Elizabeth survived her husband by five years.