|A.K.A.||Duke Karl Leopold Of Mecklenburg-Schwerin, Karl Leopold Herzog zu Mecklenburg|
|Birth||26 November 1678 (Grabow, Ludwigslust-Parchim District, Mecklenburg-Vorpommern, Germany)|
|Death||28 November 1747 (Dömitz, Ludwigslust-Parchim District, Mecklenburg-Vorpommern, Germany)|
Karl Leopold of Mecklenburg-Schwerin (26 November 1678 – 28 November 1747) was Duke of Mecklenburg-Schwerin from 1713 to 1747.
He was the second son of Frederick, Duke of Mecklenburg-Grabow, and his wife Christine von Hessen-Homburg (1653–1722). He succeeded his brother Frederick William, Duke of Mecklenburg-Schwerin, in 1713.
Karl Leopold married three times. His first wife was Sophia Hedwig of Nassau-Dietz (1690–1734), daughter of Henry Casimir II, Prince of Nassau-Dietz, and his wife Henriëtte Amalia van Anhalt-Dessau. They married on 27 May 1709 in Leeuwarden and divorced in 1710. There were no children from this marriage.
His second wife was Christine von Lepel (1692–1728), daughter of Nicolaus Friedrich von Lepel and his wife Leveka von Plessen. They married on 7 June 1710 at Doberau and divorced on 2 October 1711. There were no children from this marriage, either.
His third wife was the Grand Duchess Catherine Ivanovna of Russia, daughter of Tsar Ivan V of Russia and his wife Praskovia Saltykova. They married on 19 April 1716 in Danzig. There was one daughter born of this marriage, the Grand Duchess Anna Leopoldovna of Russia. She married Duke Anthony Ulrich of Brunswick and had 5 children. She served as Regent of Russia for her son Ivan VI from 1740 to 1741.