Karen (Christiane Andrea) Wedel-Jarlsberg, née Anker (2 November 1789 in Oslo – 19 June 1849 on Bogstad gård), was a Norwegian countess and lady in waiting.
Karen Wedel-Jarlsberg was the only surviving child and heir of Peder Anker and Anna Elisabeth Cold (1749–1803) and one of the richest heirs in Norway. She married count Herman Wedel-Jarlsberg 19 May 1807 on Bogstad.
In 1814, Norway and Sweden was united and shared the same royal house. During the visits of the royal family in Norway, it was to have a separate Norwegian court. Karen Wedel-Jarlsberg was given the task to be the head lady in waiting of the first Norwegian court since the Middle Ages. From 1817 onward, she was named overhoffmesterinne to the Swedish-Norwegian queens Hedwig Elizabeth Charlotte of Holstein-Gottorp, Désirée Clary and Josephine of Leuchtenberg: first with the title hovmastarinna (Court mistress) and from 1825 with the title overhoffmesterinne (Chief court mistress).