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Joseph L. Goldstein
Scientist

Joseph L. Goldstein

The basics

Quick Facts

Intro
Scientist
A.K.A.
Joseph Leonard Goldstein
Gender
Male
Place of birth
Kingstree
Age
84 years
The details (from wikipedia)

Biography

Joseph Leonard Goldstein (born April 18, 1940) is an American biochemist. He received the Nobel Prize in Physiology or Medicine in 1985, along with fellow University of Texas researcher, Michael Brown, for their studies regarding cholesterol. They discovered that human cells have low-density lipoprotein (LDL) receptors that remove cholesterol from the blood and that when LDL receptors are not present in sufficient numbers, individuals develop hypercholesterolemia and become at risk for cholesterol related diseases, notably coronary heart disease. Their studies led to the development of statin drugs.

Life and career

Goldstein was born in Kingstree, South Carolina, the son of Fannie (Alpert) and Isadore E. Goldstein, who owned a clothing store. Goldstein received his BSci from Washington and Lee University in 1962, and his MD from Texas University's Southwestern Medical School in 1966. Upon completion of his residency, Goldstein moved to the National Institutes of Health (NIH) in Bethesda, Maryland, where he worked in biochemical genetics. In 1972, Goldstein relocated back to the Southwestern Medical Center, accepting a post as the head of the Division of Medical Genetics.

At the Southwestern Medical Center Goldstein collaborated extensively with Michael Brown, a fellow researcher at the center who had also worked at the NIH. From 1973 to 1985, Goldstein and Brown together published over one hundred major papers. They are both listed in Thomson Reuters’ index of highly cited authors. Frequently mentioned as a candidate for nationally-prominent positions in scientific administration, Goldstein, like his colleague Michael Brown, chose to continue hands-on research.

In 1993, their postdoctoral trainees, Wang Xiaodong and Michael Briggs, purified the Sterol Regulatory Element-Binding Proteins (SREBPs), a family of membrane-bound transcription factors. Since 1993, Goldstein, Brown, and their colleagues have described the unexpectedly complex machinery that proteolytically releases the SREBPs from membranes, thus allowing their migration to the nucleus where they activate all the genes involved in the synthesis of cholesterol and fatty acids. The machinery for generating active SREBPs is tightly regulated by a negative feedback mechanism, which explains how cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances.

Goldstein is Chair, Molecular Genetics at University of Texas Southwestern Medical Center. Together, Goldstein and Brown lead a research team that typically includes a dozen doctoral and postdoctoral trainees. They have trained over 145 graduate students and postdoctoral fellows, and five of their former postdoctoral fellows (Thomas C. Südhof, Wang Xiaodong, Helen H. Hobbs, David W. Russell, and Monty Krieger) have been elected to the U.S. National Academy of Sciences. Former postdoctoral fellow Thomas Südhof received the 2013 Nobel Prize in Medicine or Physiology and Helen H. Hobbs received the 2015 Breakthrough Prize in Life Sciences.

In 1988 Goldstein received a National Medal of Science in the field of molecular genetics, and in 2003 Goldstein and Brown won the Albany Medical Center Prize in Medicine and Biomedical Research in recognition for their further work in understanding cholesterol and also the discovery of an insulin-sensitive regulator, which potentially could be used to develop treatments for diabetes mellitus. Goldstein is a member of the U.S. National Academy of Sciencesand the Institute of Medicine and he was elected a Foreign Member of the Royal Society (ForMemRS) in 1991.

Goldstein was appointed as Chairman of the Albert Lasker Medical Research Awards jury in 1995, and was a recipient of the award ten years earlier. Since 2000, Goldstein has authored a series of essays on the deep relationship between art and science that appear in the annual Nature Medicine supplement that accompanies the Lasker Awards.

Among his professional activities, Goldstein is a member of the Board of Trustees of The Howard Hughes Medical Institute and of The Rockefeller University, where he was elected as a Life Trustee in 2015. He also serves as Chairman of the Board of Scientific Counselors of the Broad Institute, and is a member of the Board of Directors of Regeneron Pharmaceuticals, Inc. He previously served on The Board of Scientific Governors of the Scripps Research Institute, a nonprofit institute that conducts biomedical research.

Awards

Joseph L. Goldstein has been awarded the following:

  • 2011 – Stadtman Distinguished Scientist Award, American Society for Biochemistry and Molecular Biology
  • 2007 – Builders of Science Award, Research!America
  • 2005 – Woodrow Wilson Awards for Public Service
  • 2005 – Herbert Tabor Award, American Society for Biochemistry and Molecular Biology
  • 2003 – Albany Medical Center Prize in Medicine and Biomedical Research
  • 2002 – Kober Medal, Association of American Physicians
  • 1999 – Warren Alpert Foundation Prize, Harvard Medical School
  • 1991 - Elected a Foreign Member of the Royal Society (ForMemRS)
  • 1988 – U.S. National Medal of Science
  • 1985 – Nobel Prize in Physiology or Medicine
  • 1985 – Albert Lasker Award for Basic Medical Research
  • 1985 – William Allan Award, American Society of Human Genetics
  • 1984 – Louisa Gross Horwitz Prize, Columbia University
  • 1981 – Gairdner Foundation International Award
  • 1980 - Elected member of the National Academy of Sciences
  • 1979 – Richard Lounsbery Award, U.S. National Academy of Sciences
  • 1978 – Passano Award, Johns Hopkins University
  • 1976 – Pfizer Award for Enzyme Chemistry, American Chemical Society

Research papers

Essays on "The Art of Science"

Since 2000, Goldstein has authored a series of essays considering science as a creative pursuit, and explores the links between the art and science. The essays appear in the journal Nature Medicine, and coincide with the annual announcement of the Lasker Awards, with which Goldstein is affiliated in the capacity of jury chairman.

  • Joseph L. Goldstein (September 2015). "A Well-Hung Horse: Sired by Knowledge and Imagination". Cell. 162 (6): 1179–1182. doi:10.1016/j.cell.2015.08.039. 
  • Joseph L. Goldstein (October 2014). "Balzac's Unknown Masterpiece: spotting the next big thing in art and science". Nature Medicine. 20 (10): 1106–1111. doi:10.1038/nm.3676. 
  • Joseph L. Goldstein (October 2013). "Juxtapositions in Trafalgar Square: tip-offs to creativity in art and science". Nature Medicine. 19 (10): 1222–1226. doi:10.1038/nm.3329. 
  • Joseph L. Goldstein (October 2012). "Paradigm shifts in science: insights from the arts". Nature Medicine. 18 (10): 1473–1477. doi:10.1038/nm.2923. 
  • Joseph L. Goldstein (October 2011). "The card players of Caravaggio, Cézanne and Mark Twain: tips for getting lucky in high-stakes research". Nature Medicine. 17 (10): 1201–1205. doi:10.1038/nm.2465. 
  • Joseph L. Goldstein (October 2010). "How to win a Lasker? Take a close look at Bathers and Bulls". Nature Medicine. 16 (10): 1091–1096. doi:10.1038/nm1010-1091. 
  • Joseph L. Goldstein (October 2009). "Lasker Awards and papal portraiture: turning fields upside down". Nature Medicine. 15 (10): 1137–1140. doi:10.1038/nm1009-1137. 
  • Joseph L. Goldstein (October 2008). "Exuberant unpredictability: sine qua non for priceless and prizeworthy biomedical research". Nature Medicine. 14 (10): 1029–1032. doi:10.1038/nm1008-1029. 
  • Joseph L. Goldstein (October 2007). "Creation and revelation: two different routes to advancement in the biomedical sciences". Nature Medicine. 13 (10): 1151–1154. doi:10.1038/nm1642. 
  • Joseph L. Goldstein (October 2006). "Venture science: climbing the ladder to telomerase, cognitive therapy and in situ hybridization". Nature Medicine. 12 (10): 1129–1132. doi:10.1038/nm1006-1129. 
  • Joseph L. Goldstein (October 2005). "60 years of winged victories for biomedical research". Nature Medicine. 11 (10): 1023–1025. doi:10.1038/nm1005-1023. 
  • Joseph L. Goldstein (October 2004). "Towering science: an ounce of creativity is worth a ton of impact". Nature Medicine. 10 (10): 1015–1017. doi:10.1038/nm1004-1015. 
  • Joseph L. Goldstein (October 2003). "It's a grand year for celebrating science". Nature Medicine. 9 (10): 1237–1238. doi:10.1038/nm937. PMID 14520362. 
  • Joseph L. Goldstein (October 2002). "Synergy and symbiosis à la Matisse-Picasso". Nature Medicine. 8 (10): 1053–1054. doi:10.1038/nm768. PMID 12357230. 
  • Joseph L. Goldstein (October 2001). "Knockout mice and test-tube babies". Nature Medicine. 7 (10): 1079–1080. doi:10.1038/nm1001-1079. 

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