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Hemin

Hemin Qing dynasty person CBDB = 62145

Qing dynasty person CBDB = 62145
The basics
Quick Facts
Intro Qing dynasty person CBDB = 62145
Countries China
Gender male
Hemin
The details
Biography

Hemin (haemin; ferric chloride heme) is an iron-containing porphyrin with chlorine that can be formed from a haem group, such as haem b found in the haemoglobin of human blood.

Chemistry

Hemin is protoporphyrin IX containing a ferric iron (Fe) ion with a coordinating chloride ligand.

Chemically, hemin differs from the related heme-compound hematin chiefly in that the coordinating ion is a chloride ion in hemin, whereas the coordinating ion is a hydroxide ion in hematin. The iron ion in haem is ferrous (Fe), whereas it is ferric (Fe) in both hemin and hematin.

Hemin is endogenously produced in the human body, for example during the turnover of old red blood cells. It can form inappropriately as a result of hemolysis or vascular injury. Several proteins in human blood bind to hemin, such as hemopexin and serum albumin.

Pharmacological use

A lyophilised form of hemin is used as a pharmacological agent in certain cases for the treatment of porphyria attacks, particularly in acute intermittent porphyria. Administration of hemin can reduce haem deficits in such patients, thereby suppressing the activity of delta-amino-levulinic acid synthase (a key enzyme in the synthesis of the porphyrins) by biochemical feedback, which in turn reduces the production of porphyrins and of the toxic precursors of haem. In such pharmacological contexts, hemin is typically formulated with human albumin prior to administration by a medical professional, to reduce the risk of phlebitis and to stabilise the compound, which is potentially reactive if allowed to circulate in free-form. Such pharmacological forms of hemin are sold under a range of trade names including the trademarks Panhematin and Normosang.

History of isolation

Haemin was first crystallised out of blood in 1853, by Ludwik Karol Teichmann. Teichmann discovered that blood pigments can form microscopic crystals. Thus, crystals of hemin are occasional referred to as 'Teichmann crystals'. Hans Fischer synthesised haemin, for which he was awarded the Nobel Prize in Chemistry in 1930. Fischer's procedure involves treating defribrinated blood with a solution of sodium chloride in acetic acid.

Forensics

Hemin can be produced from haemoglobin by the so-called Teichmann test, when haemoglobin is heated with glacial acetic acid (saturated with saline). This can be used to detect blood traces.

Other

Hemin is considered the "X factor" required for the growth of Haemophilus influenzae.

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Sources
References
http://www.pnas.org/content/61/4/1177.full.pdf
//doi.org/10.1073%2Fpnas.61.4.1177
//www.ncbi.nlm.nih.gov/pmc/articles/PMC225235
http://www.porphyriafoundation.com/content/panhematin-acute-porphyria
https://www.medicines.org.uk/emc/medicine/20795
https://www.nobelprize.org/nobel_prizes/chemistry/laureates/1930/fischer-lecture.pdf
//doi.org/10.15227%2Forgsyn.021.0053
https://www.drugs.com/cdi/hemin.html
https://www.whocc.no/atc_ddd_index/?code=B06AB01
http://www.commonchemistry.org/ChemicalDetail.aspx?ref=16009-13-5
https://pubchem.ncbi.nlm.nih.gov/compound/5318002
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