George Ernest Uhle (September 18, 1898 – February 26, 1985) was a Major League Baseball pitcher. Born in Cleveland, Ohio, he began his playing career with his hometown Cleveland Indians. After ten seasons, during which time he led the American League in wins, innings pitched, complete games, shutouts, and games started, he was traded in 1928 to the Detroit Tigers for Jackie Tavener and Ken Holloway. He went on to play with the New York Giants, New York Yankees, and again with the Indians. When his career ended in 1936, he had won 200 games. His lifetime batting average of .288 is still a record for a pitcher (not playing at any other position)
On May 25, 1929, the Detroit Tigers defeated the Chicago White Sox 6-5 in 21 innings. Uhle, who was the winning pitcher, pitched twenty innings to earn his eighth win of the season with no losses. The losing pitcher, Ted Lyons pitched all 21 innings for Chicago.