Francisco de Sande Picón (1540–1602) was the third Spanish governor and captain-general of the Philippines from August 25, 1575 to April 1580. He established the Royal City of Nueva Cáceres, now known as Naga City.
A native of Cáceres and a relative of Álvaro de Sande, he served as attorney, criminal judge, and auditor in Mexico. He succeed Guido de Lavezaris, a member of the 1543 Ruy López de Villalobos Expedition from Barra de Navidad, Jalisco, México, on August 25, 1575.
In 1575, King Philip II of Spain appointed him as the governor-general of the Philippines.
One of his first political advocacy was to disestablish vast encomiendas of wealthy Spaniards in the Philippines. In 1576, he issued a decree forbidding all officials appointed by the Crown to own encomiendas that are initially for Indios. He also established the city of Nueva Cáceres, province of Camarines Sur, Bicol region, Island of Luzon, the largest of the some 7,107 islands (under Spanish Administration till 1898, for some 350–370 years), Philippine Islands. A few years after, Spanish and Dominican prelate Domingo de Salazar requested to create monasteries for the Dominicans which was granted by Sande through King Philip II's royal decree.
During his time, the first Augustinian priests arrived to Manila on July 1, 1577 coming from Acapulco, Mexico. That same year, the Church of San Agustin was erected at the same city.
He also commissioned an expedition to Borneo in 1578 where the Sultan of Jolo became a vassal of Spain through a peace treaty signed at Río Grande de Mindanao. That same year, he attacked Borneo where the sultan of that sultanate (present day Brunei) became submissive to the Spanish officials of Manila. He also showed eagerness to conquer Moluccas from the Portuguese as well as China.
In 1579, he sent an expedition again, headed by Captain Gabriel de Ribera to Mindanao and Jolo to secure Moro submission to Spanish authority. He gone to the Rio Grande to find nothing but remnants of villages abandoned by the localities. He then established a fortress for the villages and go north to pacify rebelling Butuanons. Upon his return in Luzon, Ribera met some natives from Jolo with little tribute saying that they have nothing to give to the Spaniards since the Portuguese Estevan Rodriguez de Figueroa recently attacked their settlements.
In the same year, he denied the Franciscan fathers their burning wishes, after some 19,000 km. travel to enter China to spread Catholicism, the Chinese being stupefied when some of them disobeyed the Manila Spanish Civil Authorities and arrived at the highly controlled Portuguese trade city of Macao, where they found that they did not carry weapons, money or goods to exchange but only some religious liturgical ware for their own use and Catholic books.
He also became an auditor in the Audiencia of Mexico.