Charles William "Charlie" Grube (June 11, 1904 – June 1976) was an American football player. A native of Saginaw, Michigan, Grube attended Arthur Hill High School before enrolling at the University of Michigan. He played end for the Michigan Wolverines football team from 1923 to 1925. He played on the 1925 Michigan Wolverines football team that included quarterback Benny Friedman and fellow end Bennie Oosterbaan. Grube later played professional football for the Detroit Panthers in 1926. Grube died in 1976 at age 72 while residing in Hollywood, Florida.