Bohemond V of Antioch (1199 − January 1252) was ruler of the Principality of Antioch, a crusader state, from 1233 to his death. He was simultaneously Count of Tripoli.
Bohemond V was the son of Bohemund IV of Antioch and Plaisance of Gibelet. Like his father before him, Bohemond had a notorious dislike for the Knights Hospitaller and the neighbouring Kingdom of Armenia, preferring an alliance with the Knights Templar. Peace with Armenia was assured only shortly before his death, with the mediation of Louis IX of France.
In 1225, Bohemond was married to Cypriote queen dowager Alice of Champagne. Their childless marriage ended in annulment after July 5, 1227. His second marriage was in 1235 to Luciana di Segni, a great-niece of Pope Innocent III. He had two children:
- Plaisance of Antioch, a daughter who became the third wife of King Henry I of Cyprus in 1251
- Bohemond VI of Antioch
Bohemond V died in January 1252. Since his son and successor was only 15 at the time, he succeeded under the regency of the Dowager Princess, Luciana. However, Luciana never left Tripoli, and instead handed over the government of the principality to her Roman relatives. This made her unpopular, so the young Bohemond VI gained the approval of King Louis IX of France, who was on Crusade at the time, to get permission from Pope Innocent IV to come of age a few months early.