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Asim Duttaroy

Asim Duttaroy

The basics
Quick Facts
Gender male
The details
Biography

Asim K. Duttaroy is an Indian born American medical scientist who, since 2001, works as a Professor at the Faculty of Medicine, University of Oslo, Norway.

Duttaroy is the author of over 200 research papers and book chapters, has authored or edited several books, and also holds several international patents. His research contributions have led to several industrial developments worldwide. Duttaroy, while he worked as Professor (1990-2001) at the Rowett Institute of Nutrition and Health at the University of Aberdeen, Scotland, United Kingdom, discovered that an extract from tomato had a positive effect in the prevention of blood platelet aggregation.

However, another area of his research has been the investigation of the fatty acid transport system in human placenta and its roles in placental preferential transfer of critically important nutrients such as docosahexaenoic acid (22:6n-3) and arachidonic acid (20:4n-6) from the mother to the fetus. He has been a major contributor in understanding the roles of these fatty acids in early placentation process via VEGF/ANGPTL4 pathways, which is the step for optimal pregnancy outcome.

Duttaroy serves as Editor-In-Chief of the peer reviewed journal Food & Nutrition Research, which has an Impact Factor of 3.226. Additionally, Duttaroy serves on the editorial boards of several other journals, including Prostaglandins Leukotrienes and Essential Fatty Acids, Health and Nutrition, Bioenergetics, and Journal of Nutrition and Health.



Books

  • Cellular Proteins and Their Fatty Acids in Health and Disease
  • Human Placental Trophoblasts: Impact of Maternal Nutrition
  • Early Nutrition and Lifestyle Factors: Effects on First Trimester Placenta

Selected Articles

Duttaroy, A.K., Ray, T.K. and Sinha, A.K. (1985): Control of erythrocyte membrane microviscosity by insulin. Biochimica et Biophysica Acta 816, 187-190. https://doi.org/10.1016/0005-2736(85)90408-0

Duttaroy, A.K., Ray, T.K. and Sinha, A.K. (1986): Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. Science 231, 385-388. http://dx.doi.org/10.1126/science.3001935

Duttaroy, A.K. and Sinha, A.K. (1987): Purification and properties of prostaglandin E1/prostacyclin receptor of human blood platelets. Journal of Biological Chemistry 262, 12685-12691. http://www.jbc.org/content/262/26/12685.long

Duttaroy, A.K., Gopalswamy, N. and Trulzsch, D.V. (1987): Prostaglandin E1 binds to Z protein of rat liver. European Journal of Biochemistry 162, 615 -619. http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1987.tb10683.x/abstract

Rae, M.G., Rotondo, D., Milton, A.S. and Duttaroy, A.K. (1992): Interleukin-1 inhibits PGE2 binding to macrophage-like P388D1 cells by a cyclic AMP-independent process. Biochimica et Biophysica Acta 1138, 75-79. https://doi.org/10.1016/0925-4439(92)90154-F

Duttaroy, A.K., Hoque, L., and Paterson, B.J.P. (1993) Prostaglandin E1 binding sites in rabbit erythrocyte membrane. European Journal of Biochemistry 213, 1167 - 1173. http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1993.tb17867.x/abstract

Loh, C. L., Rotondo, D. and Duttaroy, A.K. (1993): Characterisation of PGE2 receptors expressed on human monocytic leukaemic cell line, U937. Biochimica et Biophysica Acta 1177, 43-48. https://doi.org/10.1016/0167-4889(93)90155-I

Chaudry, A.A. and Duttaroy, A.K. (1993) Purification and characterisation of a fatty acid-binding protein from human prostatic tissue. Lipids 28, 383 - 388. PMID 8316044

Duttaroy, A.K. ,Gordon, M.J., Campbell, F.M., Duthie, G.G. and James, W.P.T.: (1994) Vitamin E requirements, transport and metabolism: Role of a-tocopherol-binding proteins. Journal of Nutritional Biochemistry 5, 562 - 570. https://doi.org/10.1016/0955-2863(94)90010-8

Campbell, F. M., Taffesse, S., Gordon, M.J., and Duttaroy, A.K. (1995) Plasma membrane fatty acid-binding protein in human placenta: Identification and Characterization. Biochemical and Biophysical Research Communication 209, 1011-1017. https://doi.org/10.1006/bbrc.1995.1598

Campbell, F. M. and Duttaroy, A.K. (1995): Plasma membrane fatty acid-binding protein (FABPpm) is exclusively located in the maternal facing membranes of the placenta. FEBS Letters 375, 227-330. https://doi.org/10.1016/0014-5793(95)01216-2

Duttaroy, A.K., Gordon, M.J., Campbell, F.M., and Crosbie, L.C.(1996): Arachidonic acid uptake by human platelets is mediated by CD36. Platelets. 7, 291-295. http://dx.doi.org/10.3109/09537109609023591

Campbell, F.M., Clohessy, A., Gordon, M.J. Page, K.R., and Duttaroy, A.K. (1997) Preferential uptake of long chain fatty acids by human choriocarcinoma cells, BeWo : Role of plasma membrane fatty acid-binding protein. Journal of Lipid Research 38, 2558-2568. http://www.jlr.org/content/38/12/2558.long

Crabtree, J., Gordon, M.J., Campbell, F.M. and Duttaroy, A.K. (1998) Differential distribution and metabolism of arachidonic acid and docosahexaenoic acids by human placental cells. Molecular and Cellular Biochemistry 185, 191 - 198. http://link.springer.com/article/10.1023/A:1006852230337

Campbell, F.M., Gordon, M.J., Hoggrad, N. and Duttaroy, A.K. (1998) Interaction of free fatty acids with human leptin. Biochemical and Biophysical Research Communication 247, 654-658. https://doi.org/10.1006/bbrc.1998.8877

Campbell, F.M., Gordon, M.J., and Duttaroy, A.K.(1998) Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids. Life Sciences 63, 235-240. https://doi.org/10.1016/S0024-3205(98)00267-7

Campbell, F.M., Bush, P., Veerkamp, J.H. and Duttaroy, A.K. (1998) Distribution of membrane associated- and cytoplasmic fatty acid-binding proteins in human placenta. Placenta 19, 409-415. https://doi.org/10.1016/S0024-3205(98)00267-7

Waterman, I.J., Emisson, N. and, Duttaroy, A.K. (1998) Characterization of triacylglycerol hydrolase activities in human placenta. Biochimica et Biophysica Acta 1394, 169-176. https://doi.org/10.1016/S0005-2760(98)00105-2

Duttaroy, A.K. , Gordon, M.J., Kelly, C., Hunter, K.A., Crosbie, L., Knight-Carpenter, T., Williams (1999) Inhibitory effect of Ginkgo biloba extract on human platelet aggregation. Platelets 10, 298-305. http://dx.doi.org/10.1080/09537109975933

Duttaroy, A.K. (2000) Transport mechanisms for long chain polyunsaturated fatty acids in the human placenta. American Journal of Clinical Nutrition. 71, 315S-322S. http://ajcn.nutrition.org/content/71/1/315s.full

Hunter, K, Crosbie, L.C, Weir , A., Miller, G.J., and Duttaroy, A.K. (2000) A residential study comparing the effects of diets rich in stearic acid, oleic acid, and linoleic acid on fasting blood lipids and haemostatic variables in young healthy men. Journal of Nutritional. Biochemistry. 11, 408-416. https://doi.org/10.1016/S0955-2863(00)00097-8

Waterman, I.J., Emisson, N. and, Sattar, N.,Duttaroy, A.K. (2000) Further molecular characterisation of triacylglycerol hydrolase activity (pH 6 optima) of human placental membranes. Placenta 21, 813-823. https://doi.org/10.1053/plac.2000.0572

Duttaroy, A.K. , and Crosbie, L., Gordon MJ (2001) Effects of tomato extract on platelet aggregation in vitro. Platelets, 12, 218-227. http://dx.doi.org/10.1080/09537100120058757

Duttaroy, A.K., (2000) Cellular uptake of long chain fatty acids: role of membrane associated binding/transport proteins. Cellular and Molecular Life Sciences , 57,1360-1372. http://link.springer.com/article/10.1007%2FPL00000621

Duttaroy, A.K.. (2002) Dietary components and human platelet activity. Platelets , 13,67-75. http://dx.doi.org/10.1080/09537100120111540

Salah-uddin, H., Greaves, M., Ford, I., and Duttaroy, A.K. (2002) Distribution of arachidonic acid in platelet phospholipids in myeloproliferator disorders and NIDDM: Effects on Platelet aggregation. Molecular Cellular Biochemistry 239, 203-211. http://link.springer.com/article/10.1023/A:1020583630536

Duttaroy, A.K. and Taylor, J., Gordon, M.J., Hoggrad, N., Campbell, F.M (2002) Arachidonic acid induced stimulates internalisation of leptin by human choriocarcinoma (BeWo) cells. Biochemical and Biophysical Research Communication , 299, 432-437. https://doi.org/10.1016/S0006-291X(02)02647-5

Duttaroy, A.K. and Jøorgensen A (2004) Effects of kiwi fruits consumption on platelet aggregation and plasma in healthy human volunteers. Platelets, 15, 287-292. http://dx.doi.org/10.1080/09537100410001710290

Duttaroy, A.K. and Jøorgensen A (2005) Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells. Prostaglandins Leukotrienes and Essntl. Fatty Acids ,72, 403-408. http://www.sciencedirect.com/science/article/pii/S0952327805000414

Duttaroy, A.K. (2005) Postprandial activation of hemostatic factors: Role of dietary fats.. Prostaglandins Leukotrienes and Essntl. Fatty Acids , 72, 381-391. http://dx.doi.org/10.1080/09537100120111540

Pierre, S., Crosbie, L., and Duttaroy, A.K. (2005) Inhibitory effect of aqueous extracts of some herbs on human platelet aggregation in vitro. Platelets, 16 , 469-473. http://dx.doi.org/10.1080/09537100500129540

Tobin, K.A., Harsem, N.K., Dalet, K.T., Staff, A.C., Nebb, H.I., and Duttaroy, A.K. (2006) Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. Journal of Lipid Research 47 , 815-823. https://www.ncbi.nlm.nih.gov/pubmed/16391323

O’ Kennedy,N., Crosbie,L., Lieshout, M.V., Webb, D.J., Broom, J.,and Duttaroy, A.K. (2006) Antiplatelet activity of tomato extract. Effects on platelet function in vitro and ex vivo - a time course cannulation study in healthy humans. American Journal of Clinical Nutrition 84, 570-579. http://ajcn.nutrition.org/content/84/3/570.long

O’ Kennedy,N., Crosbie,L., Whelan,S, Luther,S., Horgan, G., Webb, D.J., Broom, J.,and Duttaroy, A.K. (2006) Effects of tomato extract on platelet function - a double-blinded crossover study in healthy humans. American Journal of Clinical Nutrition 84,561-569 . http://ajcn.nutrition.org/content/84/3/561.long

Duttaroy, A.K. (2006) Healthy Fats.. Nature, 444, 425.https://www.nature.com/nature/journal/v444/n7118/full/444425a.html

Tobin, K.A., Johnsen, G.M,Staff, A.C., and Duttaroy, A.K. (2009) Long-chain polyunsaturated fatty acids transfer across human placental choriocarcinoma (BeWo) cell line. Placenta 30:41-47DOI: http://dx.doi.org/10.1016/j.placenta.2008.10.007

Duttaroy, A.K. (2009) Transport of fatty acids across the human placenta: a review. Progress in Lipid Research 48:52-61 https://doi.org/10.1016/j.plipres.2008.11.001

Kaur, B, Jørgensen, A, Duttaroy, AK (2009) Fatty acid uptake by breast cancer cells (MDA-MB-231): Effects of insulin, leptin, adiponectin, and TNFalpha. Prostaglandins Leukotrienes and Essntl. Fatty Acids 80: 93-99. https://doi.org/10.1016/j.plefa.2009.01.002

Johnsen, GM, Weedon-Fekjær, MS, Tobin, KA, Staff, CA, Duttaroy, AK (2009 )Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. Placenta 30(12):1037-44. https://doi.org/10.1016/j.placenta.2009.10.004

Johnsen GM, Basak, S., Weedon-Fekjær MS, Staff A, Duttaroy AK, (2011) Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR-8/SVneo Placenta ,32 626-632. https://doi.org/10.1016/j.placenta.2011.06.009

Basak S, Duttaroy, AK. Leptin induces tube formation in the first trimester extravillous trophoblast cells. European Journal of Obstetrics & Gynecology and Reproductive Biology 2012, 164, 24-29. http://dx.doi.org/10.1016/j.ejogrb.2012.05.033

Basak S, Duttaroy, AK. Effects of fatty acids on angiogenic activity in the placental extravillious trophoblast cells. Prostaglandins Leukotrienes and Essntl. Fatty Acids 2013, 88, 155-162. http://dx.doi.org/10.1016/j.plefa.2012.10.001

Basak S, Duttaroy, AK. cis-9, trans-11 conjugated linoleic acid stimulates expression of angiopoietin like-4 in the placental extravillous trophoblast cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 2013, 1831, 834-843. https://doi.org/10.1016/j.bbalip.2013.01.012

Basak S, Das MK, Duttaroy AK. Fatty acid-induced angiogenesis in first trimester placental trophoblast cells: possible roles of cellular fatty acid-binding proteins. Life Sci. 2013 Nov 13;93(21):755-62. https://doi.org/10.1016/j.lfs.2013.09.024

Dizdarevic LL, Biswas D, Uddin MD, Jørgenesen A, Falch E, Bastani NE, Duttaroy AK.. Inhibitory effects of kiwifruit extract on human platelet aggregation and plasma angiotensin-converting enzyme activity. Platelets. 2014;25(8):567-75. http://dx.doi.org/10.3109/09537104.2013.852658

Biswas D, Uddin MM, Dizdarevic LL, Jørgensen A, Duttaroy AK. Inhibition of angiotensin-converting enzyme by aqueous extract of tomato. Eur J Nutr. 2014 Dec;53(8):1699-706. http://link.springer.com/article/10.1007%2Fs00394-014-0676-1

Das MK, Basak S, Ahmed MS, Attramadal H, Duttaroy AK Connective tissue growth factor induces tube formation and IL-8 production in first trimester human placental trophoblast cells. Eur J Obstet Gynecol Reprod Biol. 2014, 181:183-8. doi: 10.1016/j.ejogrb.2014.07.045.

Basak S, Das MK, Srinivas V, Duttaroy AK. The interplay between glucose and fatty acids on tube formation and fatty acid uptake in the first trimester trophoblast cells, HTR8/SVneo. Mol Cell Biochem. 2015;401(1-2):11-9. http://link.springer.com/article/10.1007%2Fs11010-014-2287-9

Pandya AD, Das MK, Sarkar A, Vilasagaram S, Basak S, Duttaroy AK. Tube formation in the first trimester placental trophoblast cells: Differential effects of angiogenic growth factors and fatty acids. Cell Biol Int. 2016 Jun;40(6):652-61. http://onlinelibrary.wiley.com/doi/10.1002/cbin.10601/abstract;jsessionid=550F23F2176778FAE48F8F116A925F1C.f02t04

O'Kennedy N, Raederstorff D, Duttaroy AK (2016). Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient. Eur J Nutr. 56, 461-482. DOI: 10.1007/s00394-016-1265-2 Eur J Clin Nutr. 2016 Nov 23. doi: 10.1038/ejcn.2016.222. http://link.springer.com/article/10.1007%2Fs00394-016-1265-2

O'Kennedy N, Crosbie, L., Song, H.J., Zhang, X., Horgan, G., Duttaroy AK (2016). A randomised controlled trial comparing a dietary antiplatelet, the water-soluble tomato extract Fruitflow, with 75 mg aspirin in healthy subjects. Eur J Clin Nutr doi: 10.1038/ejcn.2016.222 http://www.nature.com/ejcn/journal/vaop/ncurrent/full/ejcn2016222a.html

Duttaroy, A.K. Docosahexaenoic acid supports feto-placental growth and protects cardiovascular and cognitive function: A mini review European J Lipid Science and Technology 8 March 2016F http://onlinelibrary.wiley.com/doi/10.1002/ejlt.201500496/abstract

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