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Yenny Sinisterra (born 4 May 2000) is a Colombian weightlifter. She won the silver medal in the women's 55 kg event at the 2019 Pan American Games held in Lima, Peru. A month earlier, at the 2019 Junior World Weightlifting Championships held in Suva, Fiji, she won the silver medal in the women's 55 kg event.
In 2017, she won the gold medal in the women's 53 kg event at the Bolivarian Games held in Santa Marta, Colombia. In that same year, she also competed in the women's 53 kg event at the 2017 World Weightlifting Championships held in Anaheim, United States. The following year, she won the gold medal in the women's 53 kg event at the 2018 South American Games held in Cochabamba, Bolivia. She also competed in the women's 55 kg event at the 2018 World Weightlifting Championships held in Ashgabat, Turkmenistan.
In 2019, she competed in the women's 55 kg event at the World Weightlifting Championships held in Pattaya, Thailand. She finished in 5th place.
In February 2020, she was provisionally suspended after testing positive for the anabolic steroid boldenone. As of December 2020, her case is being contested at the Court of Arbitration for Sport as she may have ingested it after eating tainted meat and in Colombia boldenone is used for fattening cattle.