Quick Facts
Biography
Virginia L. Miller is a microbiologist known for her work on studying the factors leading to disease caused by bacteria. Miller is an elected fellow of the American Academy of Microbiology (2003) and a former Pew Charitable Trust Biomedical Scholar (1989).
Education and career
Miller has a B.A. from the University of California, Santa Barbara (1979). She earned her Ph.D. from Harvard University in 1985 where she worked on the expression of genes associated with Cholera toxin. Following her Ph.D., she was a postdoc at Stanford University. She moved to the University of California, Los Angeles in 1988 and earned tenure in 1994. She moved to Washington University in St. Louis in 1996, and then to the University of North Carolina at Chapel Hill in 2008. As of 2021, Miller is a professor of genetics, microbiology, and immunology at the University of North Carolina at Chapel Hill.
Research
Miller is known for her research into bacterial pathogenesis, the factors leading to the onset of disease from specific species of bacteria. Her early research examined the synthesis of the cholera toxin by Vibrio cholerae and identified environmental signals that lead V. cholerae to express the proteins needed to make the cholera toxin. She went on to examine the mechanisms by which another bacteria pathogen - Yersinia pestis - enters cells and cause disease. She has also worked on how Salmonella and Klebsiella pneumoniae cause disease.In brief, she mostly worked in the areas of Microbiology (69.74%), Yersinia enterocolitica (51.32%) and Virulence (48.03%).
Awards and honors
In 1989, Miller was named a Pew Scholar. In 2003, Miller was elected a fellow of the American Academy of Microbiology.
Selected publications
- Miller, Virginia L.; Taylor, Ronald K.; Mekalanos, John J. (1987-01-30). "Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein". Cell. 48 (2): 271–279. doi:10.1016/0092-8674(87)90430-2. ISSN 0092-8674. PMID 3802195. S2CID 28576010.
- Miller, V L; Mekalanos, J J (1988-06-01). "A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR". Journal of Bacteriology. 170 (6): 2575–2583. doi:10.1128/jb.170.6.2575-2583.1988. PMC 211174. PMID 2836362.
- Taylor, R. K.; Miller, V. L.; Furlong, D. B.; Mekalanos, J. J. (1987-05-01). "Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin". Proceedings of the National Academy of Sciences. 84 (9): 2833–2837. Bibcode:1987PNAS...84.2833T. doi:10.1073/pnas.84.9.2833. ISSN 0027-8424. PMC 304754. PMID 2883655.
