Suzanne Zukin

R. Suzanne Zukin is an American neuroscientist and a professor of neuroscience who directs a research lab as a F. M. Kirby Chair in Neural Repair and Protection and director of the Neuropsychopharmacology Center at Albert Einstein College of Medicine. Zukin's areas of research include neurodegenerative disorders, Ischemia, Epigenetics and Autism and uses molecular biology approaches to research these disorders. Zukin has made seminal contributions to the understanding of NMDA and AMPA receptor function and activity.

After receiving a bachelor's degree from Bryn Mawr College in 1970, Zukin started her path as a molecular biologist with an understanding of protein structure-function relationships while working on her doctoral dissertation with Donald P. Hollis at Johns Hopkins Medical School. She subsequently pursued postdoctoral work with Daniel E. Koshland Jr. at UC Berkeley where she investigated ligand binding and conformational changes in sensory receptors.

In 1977 Suzanne Zukin joined the department of Biochemistry at Albert Einstein College of Medicine.

Currently, the lab is part of the Neuroscience department at Albert Einstein, where Zukin presides as Director of the Neurophsycopharmacology Center and F.M. Kirby Chair in Neural Repair and Protection.

Currently, the lab is pursuing the following research questions related to molecular mechanisms of dysregulation of gene expression of synaptic proteins:

Epigenetic control of synaptic proteins: The Zukin lab researches epigenetic mechanisms that underlie neuronal death in animal models of stroke. They investigate the role of the gene silencing transcription factor RE1-silencing transcription factor (REST) and REST-dependent epigenetic remodeling of genes encoding synaptic proteins. The lab also pursues REST mediated experience-tuning expression of NMDA receptors during development, demonstrating that maternal deprivation disrupts a REST mediated switch to mature NMDA receptor expression

Molecular pathways leading to aberrations in Autism and fragile X syndrome: The Zukin lab aims to identify protein expression dysregulation that may result in the phenotypes observed in autism spectrum disorders. The lab has found that the downstream targets of mTORC2, Rho GTPase Rac1 and LIMK exhibit increased expression in a mouse model of autism. Elevated expression of proteins in this pathway are causally related to reduced activity of the actin depolymerizing factor Cofilin, a major determinant of dendritic spine morphology. Another marker of fragile X syndrome that the lab identified is an elevation of GluA2 (GluR2) mRNA as a result of increased CPEB3 protein expression. Elevated GluA2 mRNA increases the percent of AMPA receptors containing GluA2, thus potentially altering the transmission properties and excitation properties of neurons in the brains of individuals with autism spectrum disorders.

Zukin has published almost 200 papers in peer-reviewed scientific journals

Notable research articles:
Pyronneau A, Qionger H, Hwang J-Y, Contractor A, Zukin RS. Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome. Sci Signal 10: pii: eaan0852, 2017. PMID:29114038.  

Rodenas-Ruano A, Chávez AE, Cossio MJ, Castillo PE, Zukin RS.  REST-dependent epigenetic remodeling drives the developmental switch in synaptic NMDA receptors in vivo. Nat Neurosci 15:1382-90, 2012. PMID: 22960932

Noh KM*, Hwang JY*, Follenzi A, Athanasiadou R, Miyawaki T, Greally JM, Bennett MVL, Zukin RS. Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death. Proc Natl Acad Sci USA 109:E962-71, 2012. PMID: 22371606

Udagawa T, Swanger SA, Takeuchi K, Kim JH, Nalavadi V, Shin J, Lorenz LJ, Zukin RS, Bassell GJ, Richter JD. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Mol Cell 47:253-66, 2012. PMID: 22727665

Skeberdis VA, Chevaleyre V, Lau CG, Goldberg JH, Pettit DL, Suadicani SO, Lin Y, Bennett MV, Yuste R, Castillo PE, Zukin RS. PKA regulates calcium permeability of NMDA receptors. Nat Neurosci 9:501-10, 2006. PMID: 16531999

Lan J-Y, Skeberdis VA, Jover T, Grooms SY, Lin Y, Araneda RC, Zheng X, Bennett MVL, Zukin RS. Protein kinase C modulates NMDA receptor trafficking and gating. Nat Neurosci 4: 382-390, 2001. PMID: 11276228

2009 McKnight Foundation Neuroscience of Brain Disorders Award

Simons Foundation Autism Research Initiative

F.M. Kirby Chair in Neural Repair and Protection

Director of the Neurophsycopharmacology Center at Albert Einstein College of Medicine

Standing member of the NIH Study Section on Neural Oxidative Metabolism and Death for the National Institute for Neurologic Disorders & Stroke

2014 Brain and Behavior Research Foundation Distinguished Investigator award for "REST-dependent epigenetic remodeling of NMDA receptors as a risk factor in schizophrenia."

Frontiers in Neuroscience

Genetics & Epigenetics

Journal of Neuroscience

Neurobiology of Disease

Molecular Brain Research

Journal of Biological Chemistry

Molecular Pharmacology