Shigeo Ohno

Shigeo Ohno (大野 茂男, Ōno Shigeo, born March 1952) is a Japanese molecular biologist and professor at Yokohama City University School of Medicine, known for his pioneer research on Protein Kinase C and cell polarity.

Ohno was born in 1952 in Niigata prefecture, Japan, and received his B.S. in 1975 and his Ph.D. in 1980 from the University of Tokyo. He served as a postdoctoral fellow at the Cancer Institute, Japanese Foundation for Cancer Research to investigate the cDNA of Interferon gene with Tadatsugu Taniguchi. He was a research associate at Tokyo Metropolitan Institute of Medical Science to study molecular cloning of Calpain and Protein Kinase C. He became a professor of Biochemistry at Yokohama City University School of Medicine in 1991.

In 1998, he and his colleagues found the atypical PKC-specific interacting protein (ASIP) which is mammalian homologue of Caenorhabditis elegans Par3. This led to the finding of a conserved Par3-Par6-atypical PKC complex responsible for regulating cell polarity.

• 1989: Young Investigator Award (Japanese Biochemical Society)
• 1991: Incitement Award (Japanese Cancer Association)
• 2002: Kihara Memorial Foundation Academic Award

Ohno previously served as an editor of The Journal of Biochemistry.