
Quick Facts
Biography
Shai Efrati (Hebrew: שי אפרתי, born 1971) is an Israeli physician, an associate professor at the Sackler Faculty of Medicine and the Sagol School of Neuroscience at Tel Aviv University as well as director of the Sagol Center for Hyperbaric Medicine and Research at the Yitzhak Shamir Medical Center in Israel. As of 2008 Efrati has served as chairman of the Israeli Society for Diving and Hyperbaric Medicine.
Education and career
Efrati completed his M.D. at Ben Gurion University between 1994 and 2000. He later completed his residency, specializing in internal medicine, between 2001 and 2004 with the Department of Internal Medicine of Yitzhak Shamir Medical Center. In 2003, he continued his training in diving and hyperbaric medicine at the Israel Naval institute in Haifa. He specialized in nephrology. From 2005 to 2007 he was the head of the Nephrology Division and the Head of Research and Development unit at Yitzhak Shamir Medical Center since 2015.
Efrati is co-founder and Scientific Director of Hospitech Respiration Ltd., founded in 2006 and based in Israel. The company engages in the development of respiratory tract management solutions for mechanically ventilated patients. The solution is based on the AnapnoGuard system, a continuous closed loop control system that prevents complications related to prolonged mechanical ventilation by continuously monitoring CO2 levels above the cuff and adjusting cuff pressure required to maintain the seal at appropriate pressure.
Research work
In 2008, Efrati founded and now directs the Sagol Center for Hyperbaric Medicine and Research at Tel Aviv University and Yitzhak Shamir Medical Center, where he oversees and collaborates with other scientists and manages a large hyperbaric medicine and research facility. The center currently treats up to 200 patients per day.
Efrati has initiated a research program focusing on neuroplasticity and cognitive rehabilitation by the use of Hyperbaric Oxygen Therapy (HBOT). In the first clinical studies, it was proved that HBOT can induce neuroplasticity and improves neurocognitive functions in post stroke and Traumatic Brain Injury (TBI) years after the acute Insult. The clinical results gained from the research program have led to ongoing cooperation between a multidisciplinary team focused on the regenerative effects of hyperbaric oxygen in various brain injuries such as stroke ,post-concussion syndrome (PCS), Traumatic Brain Injury, Alzheimer's disease as well with a special focus on age-related functional decline.
In his studies, it was demonstrated that HBOT can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse.
Selected papers
- Tal S, Hadanny A, Sasson E, Suzin G, Efrati S (2017). "Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients". Frontiers in Human Neuroscience. 11: 508. doi:10.3389/fnhum.2017.00508. PMC 5654341. PMID 29097988.
- Vadas D, Kalichman L, Hadanny A, Efrati S (2017). "Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance". Frontiers in Integrative Neuroscience. 11: 25. doi:10.3389/fnint.2017.00025. PMC 5623811. PMID 29021747.
- Tal S, Hadanny A, Berkovitz N, Sasson E, Ben-Jacob E, Efrati S (2015). "Hyperbaric oxygen may induce angiogenesis in patients suffering from prolonged post-concussion syndrome due to traumatic brain injury". Restorative Neurology and Neuroscience. 33 (6): 943–51. doi:10.3233/RNN-150585. PMID 26484702.
- Efrati S, Golan H, Bechor Y, Faran Y, Daphna-Tekoah S, Sekler G, Fishlev G, Ablin JN, Bergan J, Volkov O, Friedman M, Ben-Jacob E, Buskila D (2015). "Hyperbaric oxygen therapy can diminish fibromyalgia syndrome--prospective clinical trial". PLOS ONE. 10 (5): e0127012. Bibcode:2015PLoSO..1027012E. doi:10.1371/journal.pone.0127012. PMC 4444341. PMID 26010952.
- Boussi-Gross R, Golan H, Volkov O, Bechor Y, Hoofien D, Beeri MS, Ben-Jacob E, Efrati S (July 2015). "Improvement of memory impairments in poststroke patients by hyperbaric oxygen therapy". Neuropsychology. 29 (4): 610–21. doi:10.1037/neu0000149. PMID 25384125.
- Efrati S, Ben-Jacob E (March 2014). "Reflections on the neurotherapeutic effects of hyperbaric oxygen". Expert Review of Neurotherapeutics. 14 (3): 233–6. doi:10.1586/14737175.2014.884928. PMID 24471697.
- Efrati S, Ben-Jacob E (2014). "How and why hyperbaric oxygen therapy can bring new hope for children suffering from cerebral palsy--an editorial perspective". Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc. 41 (2): 71–6. PMID 24851543.
- Efrati S, Fishlev G, Bechor Y, Volkov O, Bergan J, Kliakhandler K, Kamiager I, Gal N, Friedman M, Ben-Jacob E, Golan H (2013). "Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial". PLOS ONE. 8 (1): e53716. Bibcode:2013PLoSO...853716E. doi:10.1371/journal.pone.0053716. PMC 3546039. PMID 23335971.
- Boussi-Gross R, Golan H, Fishlev G, Bechor Y, Volkov O, Bergan J, Friedman M, Hoofien D, Shlamkovitch N, Ben-Jacob E, and Efrati S (2013). "Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury - Randomized Prospective Trial". PLoS One. 8: e79995. doi:10.1371/journal.pone.0079995.
- Hadanny A, Abbott S, Suzin G, Bechor Y, and Efrati S (2018). "Effect of Hyperbaric Oxygen Therapy on Chronic Neurocognitive Deficits of Post-Traumatic Brain Injury Patients: Retrospective Analysis". BMJ Open. 8: e023387. doi:10.1136/bmjopen-2018-023387.
- Hadanny A, Bechor Y, Catalogna M, Daphna-Tekoah S, Sigal T, Cohenpour M, Lev-Wiesel R, and Efrati S (2018). "Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering from Fibromyalgia with a History of Childhood Sexual Abuse-Randomized Controlled Trial". Front Psychol. 9: 2495. doi:10.3389/fpsyg.2018.02495. PMC 6304433. PMID 30618929.
- Shapira R, Solomon B, Efrati S, Frenkel D, and Ashery U (2018). "Hyperbaric Oxygen Therapy Ameliorates Pathophysiology of 3xtg-Ad Mouse Model by Attenuating Neuroinflammation". Neurobiol Aging. 62: 105–19. doi:10.1016/j.neurobiolaging.2017.10.007.
- Leitman M, Fuchs S, Efrati S, Hadanny A, and Vered Z (2020). "The effect of hyperbaric oxygenation therapy on myocardial function". The International Journal of Cardiovascular Imaging. doi:10.1007/s10554-020-01773-0. PMID 31953651.