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Samuel Earle (28 November 1760 – 24 November 1833) was a United States Representative from South Carolina. Born in Frederick County, Virginia, he moved to South Carolina in 1774; he participated in the American Revolutionary War, entering the service as an ensign in the 5th South Carolina Regiment in 1777 and leaving as captain of a company of rangers in 1782. He was a member of the South Carolina House of Representatives from 1784 to 1788, and was a delegate to the State convention that ratified the U.S. Constitution on 12 May 1788; he was a delegate to the South Carolina Constitutional Convention in 1790.
Earle was elected as a Republican to the Fourth Congress, serving from 4 March 1795 to March 3, 1797. He died in Pendleton District, South Carolina; interment was in Beaverdam Cemetery, Oconee County, South Carolina.
Elias Earle, Samuel's uncle, and John Baylis Earle, his cousin, were also U.S. Representatives from South Carolina.