Patrick Cramer

Patrick Cramer studied chemistry at the Universities of Stuttgart and Heidelberg (Germany) from 1989 until 1995. He completed a part of his studies as ERASMUS scholar at the University of Bristol in the UK. As a research student he also worked in the lab of Sir Alan Fersht in Cambridge, UK at the MRC Laboratory for Molecular Biology (LMB) site. In 1995 until 1998 he worked as a PhD student in laboratory of Christoph W. Müller at the European Molecular Biology Laboratory (EMBL) in Grenoble, France. He obtained his PhD in natural sciences (Dr. rer. nat.) from the University of Heidelberg in 1998. From 1999 until 2001 Cramer worked as postdoctoral researcher and fellow of the German Research Foundation (DFG) in the laboratory of the later Nobel Prize laureate Roger D. Kornberg at Stanford University, USA.

In 2001 Patrick Cramer returned to Germany where he obtained a tenure-track professorship for biochemistry at the Gene Center of the University of Munich (Ludwig Maximilians University, LMU where he was later, in 2004, appointed full professor of biochemistry. Patrick Cramer headed the Gene Center of the University of Munich for 10 years, from 2004 until 2013. He also served as Dean of the School of Chemistry and Pharmacy from 2007 to 2009, and as Director of the Department of Biochemistry from 2010 to 2013. Cramer also was a member of the University Research Board from 2007 to 2013 and speaker of the research network grant SFB464 of the German Research Council (DFG).

On January 1, 2014 Patrick Cramer was appointed Director at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany.

Patrick Cramer conducts basic research as the head of the Department of Molecular Biology at the Max Planck Institute in Göttingen. He also works as a science manager and a honorary professor at the University of Göttingen. During his postdoctoral research with Roger Kornberg, Cramer determined the atomic, three-dimensional structure of RNA polymerase II, one of the biggest enzymes in the cell nucleus. This work played a decisive role when the Nobel Prize in chemistry was awarded to Roger Kornberg in 2006 for studies of the molecular basis of eukaryotic transcription.

The laboratory of Patrick Cramer investigates the molecular mechanisms and systemic principles of gene transcription in eukaryotic cells. The laboratory uses integrated structural biology methods, including X-ray crystallography, cryo-electron microscopy, and biochemical tools. The Cramer laboratory also uses functional genomics and computational biology approaches to study the principles of transcription in living cells.

The group of Patrick Cramer created the first molecular movie of transcription initiation and elongation. Moreover, Patrick Cramer developed methods to analyze fundamental aspects of RNA metabolism in cells by integrating aspects of both molecular and systems biology. His long-term goal is to understand the expression and the regulation of the genome. The laboratory thus pioneers an approach that combines structural and genome-wide methods and may be referred to as molecular systems biology.

Patrick Cramer also commits himself to the further development of life sciences in Germany and Europe. He was one of the founders of the national cluster of excellence "Center for Integrated Protein Science (CIPSM)" and initiated the construction of the new research building, the "Munich Research Center for Molecular Biosystems (BioSysM)". In addition, Cramer was one of the members of the scientific and technical advisory board of the Bavarian state government and worked on bioethics within the institute TTN. Patrick Cramer also serves as an organizer of international conferences, and on several scientific committees and advisory boards. Since 2016 Cramer chairs the Council of the European Molecular Biology Laboratory (EMBL)

Original research articles (Selection)

• Schwalb B, Michel M, Zacher B, Frühauf K, Demel C, Tresch A, Gagneur J, Cramer P: TT-seq maps the human transient transcriptome. Science. 2016 Jun 3; 352(6290):1225-8. doi: 10.1126/science.aad9841.
• Plaschka C, Hantsche M, Dienemann C, Burzinski C, Plitzko J, Cramer P: Transcription initiation complex structures elucidate DNA opening. Nature. 2016 May 19; 533(7603):353-8. doi: 10.1038/nature17990.
• Bernecky C, Herzog F, Baumeister W, Plitzko JM, Cramer P: Structure of transcribing mammalian RNA polymerase II. Nature. 2016 Jan 28; 529(7587):551-4. doi: 10.1038/nature16482.
• Plaschka C, Larivière L, Wenzeck L, Seizl M, Hemann M, Tegunov D, Petrotchenko EV, Borchers CH, Baumeister W, Herzog F, Villa E, Cramer P: Architecture of the RNA polymerase II-Mediator core initiation complex. Nature. 2015 Feb 19; 518(7539):376-80. doi: 10.1038/nature14229.
• Schulz D, Schwalb B, Kiesel A, Baejen C, Torkler P, Gagneur J, Soeding J, Cramer P: Transcriptome surveillance by selective termination of noncoding RNA synthesis. Cell. 2013 Nov 21; 155(5):1075-87. doi: 10.1016/j.cell.2013.10.024.
• Kostrewa D, Zeller ME, Armache KJ, Seizl M, Leike K, Thomm M, Cramer P: RNA polymerase II-TFIIB structure and mechanism of transcription initiation. Nature. 2009 Nov 19; 462(7271):323-30. doi: 10.1038/nature08548.
• Bushnell DA, Cramer P, Kornberg RD: Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution. Proc Natl Acad Sci U S A. 2002 Feb 5; 99(3):1218-22.
• Cramer P, Bushnell DA, Fu J, Gnatt AL, Maier-Davis B, Thompson NE, Burgess RR, Edwards AM, David PR, Kornberg RD: Architecture of RNA polymerase II and implications for the transcription mechanism. Science. 2000 Apr 28; 288(5466):640-9.

Review articles (Selection)

• Plaschka C, Nozawa K, Cramer P: Mediator Architecture and RNA Polymerase II Interaction. J Mol Biol. 2016 Jun 19; 428(12):2569-74. doi: 10.1016/j.jmb.2016.01.028.
• Sainsbury S, Bernecky C, Cramer P: Structural basis of transcription initiation by RNA polymerase II. Nat Rev Mol Cell Biol. 2015 Mar; 16(3):129-43. doi: 10.1038/nrm3952.
• Cramer P: A tale of chromatin and transcription in 100 structures. Cell. 2014 Nov 20; 159(5):985-94. doi: 10.1016/j.cell.2014.10.047.
• Cheung AC, Cramer P: A movie of RNA polymerase II transcription. Cell. 2012 Jun 22; 149(7):1431-7. doi: 10.1016/j.cell.2012.06.006.
• Cramer P: Deciphering the RNA polymerase II structure: a personal perspective. Nat Struct Mol Biol. 2006 Dec; 13(12):1042-4.

Other publications (Selection)

• Aufbruch in die molekulare Systembiology. - Essay for the anniversary edition "20 Jahre Laborjournal", Published in Laborjournal on 11 July 2014.
• Entwicklungen in der Biomedizin: Genom-Sequenzierung in Diagnose, Prävention und Therape; Systembiologie und Medizin. In: T. Rendtorff (Hrsg.): Zukunft der biomedizinischen Wissenschaften. Nomos, 2013, ISBN 978-3-8487-0849-9.
• O. Primavesi, P. Cramer, R. Hickel, T. O. Höllmann; W. Schön: Lob der Promotion. Published in Frankfurter Allgemeine Zeitung on 19 July 2013.
• J. Hacker, T. Rendtorff, P. Cramer, M. Hallek, K. Hilpert, C. Kupatt, M. Lohse, A. Müller, U Schroth, F. Voigt, M. Zichy. Biomedizinische Eingriffe am Menschen - Ein Stufenmodell zur ethischen Bewertung von Gen- und Zelltherapie. Water de Gruyter, Berlin. ISBN 978-3-11-021306-5 (2009).

• 2016 Centenary Award of the British Biochemical Society
• 2016 Advanced Grant of the European Research Council ('TRANSREGULON')
• 2015 Arthur Burkhardt Preis
• 2015 Guest Professor, Karolinska Institutet, Stockholm, Sweden
• 2012 Cross of Merit of the Federal Republic of Germany
• 2012 Paula und Richard von Hertwig Preis
• 2012 Vallee Foundation Visiting Professorship
• 2011 Feldberg Foundation Prize
• 2010 Advanced Grant of the European Research Council ('TRANSIT')
• 2010 Medal of Honour, Robert Koch Institute
• 2009 Familie-Hansen-Award, Bayer Science & Education Foundation
• 2009 Ernst-Jung-Preis for Medicine
• 2009 Member, European Molecular Biology Laboratory (EMBL)
• 2009 Member, German National Academy of Sciences (Leopoldina)
• 2008 Bijvoet Medal, Bijvoet Center for Biomolecular Research, University of Utrecht
• 2006 Gottfried-Wilhelm-Leibniz-Preis
• 2004 10th Eppendorf Award for Young European Researchers
• 2002 GlaxoSmithKline Science Award
• 2000 EMBO Young Investigator Award
• 2000 MSC Future Investigator Award