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Mark O'Toole (born 22 June 1963) is the British Roman Catholic Bishop of Plymouth.
Born in London, England, he was ordained a priest on 9 June 1990 by Basil Hume for the Archdiocese of Westminster. Between 2002 and 2008 he served as the private secretary to Cormac Murphy-O'Connor before his appointment as the Rector of Allen Hall Seminary.
On 9 November 2013, O'Toole was appointed the ninth Bishop of Plymouth by Pope Francis. He received his episcopal consecration on 28 January 2014.
In his homily during the Stella Maris Mass for seafarers on 25 September 2014 in Plymouth Cathedral, O'Toole expressed an affinity with the mission of the Apostleship of the Sea, the Catholic charity that provides pastoral and practical support to all seafarers. He said this was because his grandfather was something of a seafarer and fisherman who owned his own boat and made a living in trading goods and supplies off the West coast of Ireland.