Kai Simons

Kai Simons (born 24 May 1938) is a Finnish professor of biochemistry and cell biology living and working in Germany. Author of the concept of lipid rafts coined also the term trans-Golgi network and proposed its role in protein and lipid sorting, Co-founder and co-organizer of EMBO, ELSO, initiated the foundation of MPI-CBG, where he acted as a director (1998-2006) and a group-leader (until 2012). Co-founder and co-owner of Lipotype GmbH.

Kai Simons is a son of physics professor. It was his father, who convinced him to study medicine, however in the beginning Simons wanted to study physics. While studying in University of Helsinki, Simons spent a summer internship in Stockholm laboratory of Bengt Samuelsson Simons worked there on mechanisms of vitamin B12 absorption In his student's years together with fellow students he organized anti-taeniasis campaign, the disease common in the eastern Finland where eating raw fish is popular.

After completing his PhD in medicine in 1964, he began a postdoctoral fellowship at Rockefeller University in New York where he worked between 1966 and 1967 on blood serum protein polymorphism He came back to Helsinki in 1967, where he started to work as a Junior Investigator for the Finnish Medical Research Council at the University of Helsinki. He became a group leader in 1972 and was a biochemistry professor in 1971-79 at the medical faculty of this university In the beginning he continued his work on serum proteins. Next, together with Leevi Kääriäinen and Ossi Renkonen, he started a research team - later joined by Ari Helenius, his first PhD student and later a post doctoral researcher who became Simons' brother-in-law. After one-month stay in MRC Laboratory for Molecular Biology in Cambridge, the group started investigating a Semliki forest virus, introduced to Simons by Kääriäinenem.

In 1975 Simons came to Heidelberg (Germany), as one of the EMBL group leaders. Together with Ari Helenius he helped to develop EMBL, headed at this time by John Kendrew. In years 1982-1998 Simons was a coordinator of the Cell Biology Programm there. During this time he for the first time presented the concept of lipid rafts.

In 1999 he took part in setting up ELSO (later incorporated into EMBO), which later he presided over.

He was one of the initiators of establishing and building Max Planck Institute of Molecular Cell Biology and Genetics in Dresden (Germany), where he moved. Formally from 1998 (beginning of MPI-CBG construction) and practically from 2000 he was one of five institute's directors and also a group leader there Since 2006 he is a director emeritus.

In 2012 he started-up a biotech company Lipotype GmbH, where he is a CEO.

He is married to Carola Simons and a father of three: twins - Mikael (neurobiologist) and Katja (sociologist and spatial planning), and the youngest of three, Matias (physician).

In the beginning Kai Simons pursuited research in the field of medical biochemistry and his master's thesis as well as PhD focused on vitamin B12 absorption. After returning from his post-doc scholarship he continued research on vitamin B12 as well as on blood plasma proteins, but soon started investigating Semliki Forest Virus, focusing on its membrane and its lipid composition and their role in the virus budding and its transport, as the model for lipid and protein secretion. During this period, Simons also investigated the application of detergents in biochemistry with a special attention to their role in biological membrane research.

The virus lifecycle and how it uses components of vesicular pathways while shuttling to the cell surface, turned Simons' attention toward vesicular transport pathways and cell polarization. Applying epithelial model cells - MDCK (Madin-Darby canine kidney), he investigated lipid transport, protein sorting and their role in polarizing cells.

During these studies he described the role of trans-Golgi network (TGN) in protein and lipid sorting according to their destination. In his works from 1988, together with Gerit van Meer, Simons for the first time postulated the existence of lipid microdomains in cell membranes. Such microdomains differ in their composition from the surrounding membrane and have special functions. Simons termed these microdomains as lipid rafts. This concept was developed over the years to be presented more fully in 1997 in Nature journal by Simons and Ikonen. This paper became on of the most frequently cited works in the field of membrane research. Other Simons' paper, on role of lipid rafts in the signal transduction is second highest cited work and Simons is fourth highest cited scientist in the field of signal transduction. Kai Simons was also recognized by ISI Web of Knowledge, as one of the most cited scientist ever.

In next years, Simons continued to work on the role of lipid rafts, and more generally lipids, in cell polarization and protein sorting. He was interested also in the role of lipids and protein sorting in neurodegenerative diseases, especially in Alzheimer's disease.

His scientific record includes more than 350 scientific articles, mostly in the field of biochemistry, molecular organization of the cell, and biochemistry and physiology of a cell membrane.

Considering his work from years 1996-2007 tracked until May 2009, Simons was 12. in the list of the most frequently cited scientists in the field cell biology with 90 articles and 16 299 citations.

Kai Simons honours and awards include:

• 1975 Federation of European Biochemical Society Anniversary Prize
• 1984 Honorary Professor, University of Heidelberg, Germany
• 1989 Lamport Visiting Professor (Columbia, New York)
• 1990 Histochemical Society Lecture
• 1990 Keith R. Porter Lecture, American Society of Cell Biology
• 1991 Anders Jahre Prize for Medical Research
• 1991 NICHD Lectureship in Cell Biology
• 1993 Carl Zeiss Lecture, German Society for Cell Biology
• 1994 Harvey Society Lecture
• 1996 Dunham Lecturer, Harvard University
• 1996 Foreign Member of the American Academy of Arts and Sciences
• 1997 Academia Europaea
• 1997 Adam Neville Lecture, University of Dundee, UK
• 1997 Foreign Member of the National Academy of Sciences, USA
• 1997 Runeberg Prize, Finland
• 1998 Academy of Sciences Leopoldina
• 1998 Choh Hao Li Memorial Lecture in Biochemical Endocrinology, University of California, Berkeley
• 1999 Doctor Honoris Causa, University of Oulu, Finland
• 2000 President of the European Life Scientist Organisation
• 2001 Honorary member of the German Society for Cell Biology
• 2001 ISI Highly cited researcher
• 2001 Schleiden Medaille of Academy Leopoldina
• 2002 Hoppe-Seyler Lecture, Society of Biology and Molecular Biology Germany
• 2003 Albert Wander Prize, University of Bern, Switzerland
• 2003 Matti Äyräpää Prize, Finland
• 2003 Doctor Honoris Causa, University of Leuven, Belgium
• 2003 Honorary Professor at TU Dresden
• 2003 Prix Mondial Nessim Habif, University of Geneva, Switzerland
• 2004 Virchow Lecture and Medal, University of Würzburg, Germany
• 2005 Foundation Day Lecture, Centre for Cellular and Molecular Biology, Hyderabad, India
• 2005 van Deenen Medal, Utrecht, The Netherlands
• 2006 AIVirtanen Medal, Finland
• 2006 Honorary member of the Societas Biochemica, Biophysica et Microbiologica Fenniae
• 2007 Order of Merit of the Free State of Saxony
• 2010 Doctor honoris causa, University of Kuopio, Finland
• 2011 Doctor honoris causa, University of Geneva, Switzerland
• 2016 Robert Koch Medal

Kai Simons was and is also a member of numerous societies, committees and organisations, as well as an editor for several scientific journals.