David Baulcombe

Sir David Charles Baulcombe, FRS FMedSci (born 1952) is a British plant scientist and geneticist. As of 2017 he is a Royal Society Research Professor and Regius Professor of Botany in the Department of Plant Sciences at the University of Cambridge.

David Baulcombe was born in Solihull, West Midlands (then Warwickshire). He received his Bachelor of Science degree in botany from the University of Leeds in 1973 at the age of 21. He proceeded to the University of Edinburgh, where he received his Doctor of Philosophy in botany in 1977.

After his PhD, Baulcombe then spent the following three years as a post-doctoral fellow in North America, first at McGill University (Montreal, Quebec, Canada) from January 1977 to November 1978, and then at the University of Georgia (Athens, Georgia, United States) until December 1980. Baulcombe returned to the United Kingdom then, where he joined the Plant Breeding Institute (PBI) in Cambridge and started his career as an independent scientist. At the PBI, Baulcombe initially held the position of Higher Scientific Officer, and was promoted to Principal Scientific Officer in April 1986. In August 1988 Baulcombe left Cambridge for Norwich. He joined the Sainsbury Laboratory as a Senior Research Scientist, and also served as Head of Laboratory between 1990 and 1993 and 1999–2003. In 1998 he was appointed Honorary Professor at the University of East Anglia, and given a full professorship there in 2002. In March 2007 it was announced that Baulcombe would become the next Professor of Botany at Cambridge University as a Royal Society Research Professor, taking up his post in September 2007. He serves on several committees and study sections, was elected Member of the European Molecular Biology Organisation in 1997 and was president of the International Society of Plant Molecular Biology 2003–2004. As of 2007, he is also a senior advisor for The EMBO Journal.

In June 2009, Baulcombe was awarded a knighthood by Queen Elizabeth II. Baulcombe resides in Norwich. He is married and has four children. His interests include music, sailing and hill walking.

Contributions to science

Baulcombe's research interests and contributions to science are mainly in the fields of virus movement, genetic regulation, disease resistance, and gene silencing.

With Andrew Hamilton he discovered the small interfering RNA that is the specificity determinant in RNA-mediated gene silencing. Baulcombe's group demonstrated that while viruses can induce gene silencing, some viruses encode proteins that suppress gene silencing. After these initial observations in plants, many laboratories around the world searched for the occurrence of this phenomenon in other organisms. In 1998 Craig Mello and Andrew Fire reported a potent gene silencing effect after injecting double stranded RNA into Caenorhabditis elegans. This discovery was particularly notable because it represented the first identification of the causative agent for the phenomenon. Fire and Mello were awarded the Nobel Prize in Physiology or Medicine in 2006 for their work.

With other members of his research group at the Sainsbury Laboratory, Baulcombe also helped unravel the importance of small interfering RNA in epigenetics and in defence against viruses.

Sir David Baulcombe has received the following honours and awards:

• 2001 elected Fellow of the Royal Society (FRS)
• 2002 elected Member of the Academia Europaea
• 2002 recipient of the Ruth Allen Award, awarded by the American Phytopathological Society
• 2002 recipient of the Kumho Science International Award in Plant Molecular Biology and Biotechnology, awarded by the Kumho Cultural Foundation, Korea
• 2003 co-recipient (with Craig Mello, Andrew Fire and Thomas Tuschl) of the Wiley Prize in the Biomedical Sciences, awarded by Rockefeller University
• 2004 recipient of the M. W. Beijerinck Virology Prize, awarded by the Royal Netherlands Academy of Arts and Sciences
• 2005 elected Foreign Associate Member of the National Academy of Sciences
• 2005 co-recipient (with Craig Mello and Andrew Fire) of the Massry Prize, awarded by the Massry Foundation and the University of Southern California
• 2006 recipient of the Royal Society's Royal Medal
• 2008 co-recipient of the Benjamin Franklin Medal in Life Science, awarded by the Franklin Institute [1]
• 2008 co-recipient (with Victor Ambros and Gary Ruvkun) of the Albert Lasker Award for Basic Medical Research
• 2008 appointed Fellow of Trinity College, Cambridge
• 2009 knighted by Queen Elizabeth II in the 2009 Birthday Honours List for services to plant science.
• 2009 recipient of the Harvey Prize, granted by the Technion Israeli Institute for Technology.
• 2010 recipient of the Wolf Prize in Agriculture.
• 2012 Balzan Prizefor Epigenetics
• 2014 Gruber Prize in Genetics

Baulcombe's nomination for the Royal Society reads