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Carlos Medina Plascencia (born August 14, 1955 in León, Guanajuato) is a Mexican politician affiliated with the conservative National Action Party (PAN). He is a former mayor of León, senator and interim governor of Guanajuato (1991 – 1995). In 2005 he ran for president of the PAN but lost against Manuel Espino.
He is the son of Carlos Medina Torres and María del Carmen Plascencia Fonseca. He graduated with a bachelor's degree in chemical engineering and a master's degree in business administration from the Monterrey Institute of Technology and Higher Studies (ITESM), where he worked as a professor from 1980 to 1981. In 1985, he joined the National Action Party and a year later was elected city councilor of León. Three years later he won the mayorship of the municipality.