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Benedict Joseph Semmes (November 1, 1789 – February 10, 1863) was an American politician.
Born in Charles County, Maryland, Semmes attended the rural schools and a medical college in Philadelphia. He graduated from Baltimore Medical School in 1811 and commenced practice in Prince George's County, Maryland. He later engaged in farming.
Semmes served as a member of the Maryland House of Delegates from 1825 to 1828 and served as speaker. He served in the Maryland State Senate, and was elected as an Anti-Jacksonian to the Twenty-first and Twenty-second Congresses, serving from March 4, 1829 to March 3, 1833. He was again a member of the Maryland House of Delegates in 1842 and 1843. He lived in retirement until his death at Oak Lawn in Prince George's County.