Athel Cornish-Bowden

Athel Cornish-Bowden is a biochemist known for his numerous textbooks, particularly those on enzyme kinetics and his work on metabolic control analysis.

Athel Cornish-Bowden worked on pepsin catalysis.. This began a life long pursuit of work on enzyme catalysis and in later years work on the control of metabolism. More recently he has also turned his attention to work related to the origin and nature of life. He worked with Daniel E. Koshland Jr. and Jeremy R. Knowles.

Cornish-Bowden has authored over 200 peer-reviewed papers and nine textbooks on topics related to enzyme kinetics, mathematics and historical perspectives in science.Cornish-Bowden's research can be divided into three primary areas: Enzyme kinetics, metabolic control and the origin of life. The following lists some of the topics and selected references to the work carried out and published by Cornish-Bowden:

Mechanisms of Pepsin Catalysis

Binding of ligands to Proteins

Kinetics of nitrite reductase

Kinetics of nitrate reductase

The evolution of macromolecules

Properties of multienzyme systems

The theory of self-organizing systems

His current interests include the definition of life and the capacity for life to self-organize.

Cornish-Bowden is most well known for his introduction of the direct-linear plot for estimating enzyme parameters, his work on Hexokinase evolution and kinetics, and his insight into the control and regulation of metabolism

• Cornish-Bowden, Athel; Eisenthal, Robert (1974). "The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters". Biochemical Journal. 139 (3): 715–720. doi:10.1042/bj1390715. PMC 1166335. PMID 4854723. Cited 1716 times (Aug, 2019)

• Storer, AC; Darlison, MG; Cornish-Bowden, A (November 1975). "The nature of experimental error in enzyme kinetic measurments[sic]". The Biochemical Journal. 151 (2): 361–7. doi:10.1042/bj1510361. PMC 1172366. PMID 1218083. Cited 98 times (Aug 2019)

• Storer, AC; Cornish-Bowden, A (1 October 1976). "Kinetics of rat liver glucokinase. Co-operative interactions with glucose at physiologically significant concentrations". The Biochemical Journal. 159 (1): 7–14. doi:10.1042/bj1590007. PMC 1164031. PMID 999645. Cited 143 times (Aug 2019)

• Storer, AC; Cornish-Bowden, A (1 July 1977). "Kinetic evidence for a 'mnemonical' mechanism for rat liver glucokinase". The Biochemical Journal. 165 (1): 61–9. doi:10.1042/bj1650061. PMC 1164869. PMID 889576. Cited 139 times (Aug 2019)

• Cornish-Bowden, A (14 July 1986). "Why is uncompetitive inhibition so rare? A possible explanation, with implications for the design of drugs and pesticides". FEBS Letters. 203 (1): 3–6. doi:10.1016/0014-5793(86)81424-7. PMID 3720956. Cited 137 times (Aug 2019)

• Eisenthal, R; Cornish-Bowden, A (6 March 1998). "Prospects for antiparasitic drugs. The case of Trypanosoma brucei, the causative agent of African sleeping sickness". The Journal of Biological Chemistry. 273 (10): 5500–5. doi:10.1074/jbc.273.10.5500. PMID 9488673. Cited 96 times (Aug 2019)

• Cárdenas, ML; Cornish-Bowden, A; Ureta, T (5 March 1998). "Evolution and regulatory role of the hexokinases". Biochimica et Biophysica Acta. 1401 (3): 242–64. doi:10.1016/s0167-4889(97)00150-x. PMID 9540816. Cited 287 times (Aug 2019)

• Hofmeyr, JS; Cornish-Bowden, A (30 June 2000). "Regulating the cellular economy of supply and demand". FEBS Letters. 476 (1–2): 47–51. doi:10.1016/s0014-5793(00)01668-9. PMID 10878248. Cited 203 times (Aug 2019)

• Hucka, M; Finney, A; Sauro, HM; Bolouri, H; Doyle, JC; Kitano, H; Arkin, AP; Bornstein, BJ; Bray, D; Cornish-Bowden, A; Cuellar, AA; Dronov, S; Gilles, ED; Ginkel, M; Gor, V; Goryanin, II; Hedley, WJ; Hodgman, TC; Hofmeyr, JH; Hunter, PJ; Juty, NS; Kasberger, JL; Kremling, A; Kummer, U; Le Novère, N; Loew, LM; Lucio, D; Mendes, P; Minch, E; Mjolsness, ED; Nakayama, Y; Nelson, MR; Nielsen, PF; Sakurada, T; Schaff, JC; Shapiro, BE; Shimizu, TS; Spence, HD; Stelling, J; Takahashi, K; Tomita, M; Wagner, J; Wang, J; SBML, Forum. (1 March 2003). "The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models". Bioinformatics (Oxford, England). 19 (4): 524–31. doi:10.1093/bioinformatics/btg015. PMID 12611808. Cited 3057 times (Aug 2019)

• Letelier, JC; Soto-Andrade, J; Guíñez Abarzúa, F; Cornish-Bowden, A; Luz Cárdenas, M (21 February 2006). "Organizational invariance and metabolic closure: analysis in terms of (M,R) systems". Journal of Theoretical Biology. 238 (4): 949–61. doi:10.1016/j.jtbi.2005.07.007. PMID 16122760. Cited 269 times (Aug 2019)

• Cornish-Bowden, Athel (2012). Fundamentals of Enzyme Kinetics (4 ed.). London: Butterworths. ISBN 9783527330744. Cited 3120 times (Aug 2012)

• Cornish-Bowden, A; Cárdenas, ML (7 December 2017). "Life before LUCA". Journal of Theoretical Biology. 434: 68–74. doi:10.1016/j.jtbi.2017.05.023. PMID 28536033. Cited 10 times (Aug 2019)

• Cornish-Bowden, Athel (1976). Principles of Enzyme Kinetics. London: Butterworths. ISBN 0408707216.

• Cornish-Bowden, Athel (1979). Fundamentals of Enzyme Kinetics. London: Butterworths.

• Cornish-Bowden, Athel (1995). Fundamentals of Enzyme Kinetics (2 ed.). London: Butterworths. ISBN 1-85578-072-0.

• Cornish-Bowden, Athel (1996). Analysis of Enzyme Kinetic Datas (4 ed.). London: Oxford University Press. ISBN 0-19-854877-X.

• Cornish-Bowden, Athel (1999). Basic Mathematics for Biochemists (2 ed.). Oxford and New York: Oxford University Press. ISBN 0-19-854877-X.

• Cornish-Bowden, Athel (2004). Fundamentals of Enzyme Kinetics (3 ed.). London: Butterworths. ISBN 0408707216.

• Cornish-Bowden, Athel (2012). Fundamentals of Enzyme Kinetics (4 ed.). London: Butterworths. ISBN 9783527330744.

• Cornish-Bowden, Athel (2016). Biochemical Evolution: the Pursuit of Perfection (2 ed.). Garland Science. ISBN 978-0-8153-4552-7.