Quick Facts
Biography
Ambra A. Pozzi is an Italian American physician who is a professor of nephrology in the Vanderbilt University Medical Center. She works on matrix biology and matrix receptor biology. In 2022, she was appointed President Elect of the American Society for Matrix Biology.
Early life and education
Pozzi was born in Brescia. She earned her master's degree at the University of Milan, where she majored in biochemistry. She moved to the University of Florence for her doctoral research. Her research focused on experimental pathology. Her mentor encouraged her to study abroad, and she eventually moved to the United States. She moved to Scripps Research for postdoctoral research.
Research and career
In 2000, Pozzi joined Vanderbilt University where she focuses on matrix biology. She has two main research focuses: kidney fibrosis and endothelial cell functions. Fibrosis is the excessive deposition of extracellular matrix components (i.e. collagen) along critical nephrons (renal tubules). Fibrosis is an irreversible process, and people who get it require a kidney transplant. Pozzi showed that the cell surface receptor DDR1 is involved with the inflammation and fibrosis that can cause kidney failure.
Pozzi is on the editorial board of Matrix Biology, and has held various leadership positions within the American Society for Matrix Biology. In 2022, she became President Elect of the society.
Selected publications
- Ambra Pozzi; Peter Yurchenco; Renato V Iozzo (28 December 2016). "The nature and biology of basement membranes". Matrix Biology. 57–58: 1–11. doi:10.1016/J.MATBIO.2016.12.009. ISSN 0945-053X. PMC 5387862. PMID 28040522. Wikidata Q39063783.
- Dana M Brantley; Nikki Cheng; Erin J Thompson; et al. (1 October 2002). "Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo". Oncogene. 21 (46): 7011–7026. doi:10.1038/SJ.ONC.1205679. ISSN 0950-9232. PMID 12370823. Wikidata Q44172489.
- Monica Red Brewer; Sung Hee Choi; Diego Alvarado; Katarina Moravcevic; Ambra Pozzi; Mark A Lemmon; Graham Carpenter (26 June 2009). "The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain". Molecular Cell. 34 (6): 641–51. doi:10.1016/J.MOLCEL.2009.04.034. ISSN 1097-2765. PMC 2719887. PMID 19560417. Wikidata Q27646344.