William Little may refer to:
William Brian Little (1942–2000), founding partner of Forstmann Little & Company, a private equity firm
William Carruthers Little (1820–1881), Ontario farmer and political figure
William John Little, English surgeon who identified cerebral palsy in children
William Little (Australian poet), 19th-century Australian fiction writer and poet, see 1916 in poetry
William Little (Pittsburgh mayor) (1809–1887), politician in Pittsburgh
William Little (rugby league), rugby league footballer of the 1900s for England, and Halifax
William Little (rugby league born circa-1910), rugby league footballer of the 1930s for England, and Barrow
William Grady Little (born 1950), former manager of the Boston Red Sox and Los Angeles Dodgers
William Little (politician), Member of the Queensland Legislative Assembly, Australia