Thomas Wharton may refer to:
Thomas Wharton, 1st Baron Wharton (1495–1568), English nobleman
Thomas Wharton, 2nd Baron Wharton (1520–1572), English nobleman
Thomas Wharton (died 1622), son of the 3rd Baron Wharton, father of the 4th Baron Wharton
Thomas Wharton (anatomist) (1614–1673), English anatomist
Thomas Wharton, 1st Marquess of Wharton (1648–1715), English nobleman and politician, credited with being the lyricist of Lilliburlero
Thomas Wharton (physician), grandson of Thomas Wharton (anatomist) and "Gray's most intimate friend, .. the eldest of the three sons of Robert (1690-1752), Mayor of Durham, second son of Thomas (1652-1714), physician, eldest son of the celebrated physician and anatomist, Dr. Thomas Wharton (1614-73)" [1]
Thomas Wharton Jr. (1735–1778), American politician and 1st President of Pennsylvania
Thomas Wharton (artist), American artist
Thomas Wharton (author) (born 1963), Canadian novelist
Tiny Wharton (1927–2005), Scottish soccer referee