Tom Clarke or Thomas Clarke is the name of:
Politicians
- Thomas Clarke (Australian politician) (died 1922), member of the New South Wales Legislative Assembly
- Tom Clarke (politician) (born 1941), British Member of Parliament 1982–2015
Sportspeople
- Thomas Clarke (footballer) (born 1989), formerly with Yeovil Town FC
- Tom Clarke (Australian footballer) (1906–1981), Australian rules footballer who played for Essendon
- Thomas Clarke (skeleton racer) (1911–1969), British skeleton racer
- Tom Clarke (footballer) (born 1987), currently with Preston North End FC
Musicians
- Tom Clarke (musician) (born 1986), lead singer of The Enemy
- Tom Clarke (Sparkles*), (born 1988), musician, music producer, lead singer of Area 11
Religious figures
- Thomas Clarke (Archdeacon of Macclesfield) (1907–1965), British Anglican priest in the third quarter of the 20th century
- Thomas Clarke (Dean of Barbados) (died 1900), British colonial Anglican priest
Others
- Sir Thomas Clarke (judge) (1703–1764), English master of the rolls, 1754–1764
- Thomas Curtis Clarke (1827–1901), railway engineer, builder and author
- Thomas B. Clarke (1848–1931), art collector from New York City
- Tom Clarke (Irish republican) (1858–1916), revolutionary leader involved in the 1916 Easter Rising
- Thomas Shields Clarke (1860–1920), American artist
- Tom Clarke (writer) (1918–1993), British television writer
Fictional characters
- Tom Clarke, a fictional character in the TV miniseries Taken played by Ryan Hurst
- Thomas Clarke, character in Wizards vs Aliens