Susan Laura Mizruchi (July 13, 1959) is an American academic.
Mizruchi's father Ephraim was a sociologist. Her mother Ruth was of Israeli Jewish descent. She has two brothers, David and Mark. Susan Mizruchi attended Washington University graduating with bachelor of arts degrees in English and history in 1981. She completed a doctorate in English at Princeton University in 1985, and began teaching at Boston University in 1986. In 1996, Mizruchi declined a Fulbright visiting professorship to Tel Aviv University. She was awarded a Guggenheim Fellowship in 2001. She accepted funding from the Fulbright Program in 2015, and was appointed William Arrowsmith Professor in the Humanities at Boston University in 2017.