René of Guise, Marquis d'Elbeuf (14 August 1536 – 14 December 1566) was the youngest son of Claude of Lorraine, Duke of Guise and Antoinette of Bourbon-Vendôme.
René was born at Joinville, Haute-Marne. He married Louise de Rieux (1531 – c. 1570) on 3 February 1555. They had two children:
Charles de Lorraine, Duc d'Elbeuf (1556–1605)
Marie de Lorraine (21 August 1555 – c. 1605), styled Mademoiselle d'Elbeuf, married at Joinville on 10 November 1576 Charles de Lorraine-Guise, Duc d'Aumale and had issue.
He served as French ambassador to Scotland, and accompanied his sister Mary of Guise on her entrance to that country in 1561. He was also a patron of the arts, particularly of composer Pierre Clereau of Lorraine.