Michael or Mike Burke may refer to:
Michael Burke, Irish economist
Michael E. Burke (1863–1918), American politician from Wisconsin
Michael Burke (soccer) (born 1977), former MLS player for D.C. United
Michael Burke (Gaelic footballer) (born 1985), inter-county Gaelic football player for Meath
Michael Burke, 10th Earl of Clanricarde (1686–1726), Irish peer
Michael Burke (New South Wales colonial politician) (1843–1909), New South Wales politician
Michael Burke (Australian politician) (1865–1937), New South Wales politician
Michael Reilly Burke (born 1964), American actor
E. Michael Burke (1916–1987), OSS + CIA operative, circus and television executive, president of several New York sports teams
Mike Burke (shortstop) (1854–1889), Major League Baseball player in 1879
Mike Burke (strongman) (born 1974), American professional strongman competitor
Mike Burke (journalist), American journalist and senior producer of Democracy Now!
Mike Burke (rugby league), former rugby player for the Parramatta Eels
Mike Burke (punter), punter for the 1974 Los Angeles Rams