Leone may refer to:
Geography
- Leone, American Samoa
- Monte Leone, mountain in the Leone-Gruppe as part of Western Alps
- Sierra Leone, independent nation in West Africa
Given name
- Leone Battista Alberti, Italian Renaissance humanist polymath
- Leone Caetani, Italian politician
- Leone de' Sommi, Italian writer
- Leone Ginzburg, Italian journalist
- Leone Leoni (1509-1590), Italian Renaissance sculptor and medallist
- Leone Sforza, Italian condottiero
- Leone Strozzi, Italian condottiero
Surname
- Carl Leone (b. 1976), Canadian businessman and criminal
- Dominic Leone (born 1990), American baseball player
- Giacomo Leone (b. 1971), Italian long-distance runner
- Giovanni Leone (1908 – 2001), Italian politician who served as president and prime minister
- Giuseppina Leone (b. 1971), Italian athlete
- Jason Leone, former drummer for Michigan heavy metal band Battlecross
- L. E. Leone (formerly Dan Leone), American food critic
- Matthew Leone (b. 1981), bassist of Madina Lake and twin of Nathan Leone
- Miriam Leone (b. 1985), Italian television personality and beauty pageant titleholder
- Nathan Leone (b. 1981), lead singer of Madina Lake and twin of Matthew Leone
- Rob Leone, (b. 1976), Canadian politician
- Sergio Leone (1929 – 1989), Italian film director
- Sunny Leone (b. 1981), Indo-Canadian model and actress