John Vaughan, 1st Viscount Lisburne (7 December 1667 – 20 March 1721), of Trawsgoed, Cardiganshire, was a Welsh nobleman.
The son of Edward Vaughan and grandson of Sir John Vaughan, he was created Baron Fethard and Viscount Lisburne, in the Peerage of Ireland, on 5 June 1695. He represented Cardiganshire in the House of Commons from 1694 to 1698.
Vaughan married his first wife, Lady Malet Wilmot (d. 1709), daughter of John Wilmot, 2nd Earl of Rochester, on 18 August 1692. They had six children:
John Vaughan, 2nd Viscount Lisburne (c.1695–1741)
Wilmot Vaughan, 3rd Viscount Lisburne (d. 1766)
Hon. Henry Vaughan, died unmarried
Lady Anne Vaughan, married Sir John Prideaux, 6th Baronet
Lady Elizabeth Vaughan
Lady Letitia Vaughan