Jean Pierre Marie Olivier Germain Defraigne (French: [dəfʁɛɲ]; 19 April 1929 – 15 March 2016) was a Belgian liberal politician and minister for the Liberal Reformist Party (PRL).
Defraigne graduated as a doctor in law at the Université de Liège and was a lawyer and alderman in Liège. He was member of the Belgian Chamber of Representatives (1965–1974 and 1977–1989) and senator in the Belgian Senate (1974–1977) for the PRL and was President (1981–1988) of the Belgian Chamber of Representatives of public work (1974–1976). In 1983, Jean Defraigne was appointed as minister of state.