Hōjō Ujikuni (北条 氏邦, 1541 – September 19, 1597) was a samurai of the Sengoku period, and the third son of Hōjō Ujiyasu. Ujikuni was a high-ranking commander in the invasion of Kozuke. He was also the castellan (castle lord) in command of Hachigata Castle in Musashi province, which came under siege twice, in 1568 and in 1590. Along with Hojo Ujiteru, failed to stop Takeda Shingen's retreat in the Battle of Mimasetoge.
After losing his castle to Toyotomi Hideyoshi, Ujikuni aided in the defense of the Hōjō's central home castle, Odawara. The Siege of Odawara would be the Hōjō's final stand and marks the end of their power and prominence.