Henry Moore Sandford, 1st Baron Mount Sandford (28 July 1751 – 29 December 1814), was an Irish landowner and politician.
Sandford was the son of Henry Sandford by the Honourable Sarah Moore, daughter of Stephen Moore, 1st Viscount Mountcashell. He was returned to the Irish House of Commons for Roscommon Borough in 1776, a seat he held until 1783 and again between 1791 and 1800. The latter year he was elevated to the Peerage of Ireland as Baron Mount Sandford, of Castlerea in the County of Roscommon, with remainder in default of male issue of his own, to his brothers William and George, and the heirs male of their bodies.
Lord Mount Sandford married Katherine Oliver, daughter of Silver Oliver, in 1780. They had no surviving children. Mount Sandford died in December 1814, aged 63, and was succeeded in the barony according to the special remainder by his nephew Henry Sandford, the son of William Sandford. Lady Mount Sandford died in October 1818.