George Clarke (1676 – 12 January 1760) was a colonial governor of New York. He was also known as George Clarke of Hyde, which was the ancestral home of the Clarke family in Cheshire. He became Secretary of the Province of New York in 1703. Along with his wife, Anne Hyde, he purchased land in Hempstead, Long Island, New York, and built an estate called Hyde Park. He became acting colonial governor of New York in 1736 following the death of William Cosby, serving until George Clinton arrived in 1743 to replace Cosby. Clarke then held the post of Lieutenant Governor until 1747.
In 1741, Clarke was marginally involved in the suppression of the New York Conspiracy of 1741, a plot much-disputed by historians on the part of African slaves and poor white settlers to overthrow the colonial government by setting fires in New York City in March 1741.
On his return journey to England, with the fortune he had amassed in America, he was captured by a French cruise boat. After a short time he was released. He died in Chester, England, on 12 January 1760, aged 84. He is buried in Chester Cathedral, where there is a monument to him.
Clarke was the nephew of British administrator William Blathwayt. The British athlete and politician Sebastian Coe is descended from George Clarke, who was his seven-times-great-grandfather, via a son who lived in Jamaica.