Andrew Smith may refer to:
Sports
- Andrew Smith (badminton) (born 1984), English badminton player
- Andrew Smith (basketball, born 1990) (1990–2016), American basketball player
- Andrew Smith (basketball, born 1992), American-Latvian basketball player
- Andrew Smith (Canadian runner) (born 1979), Canadian runner and World Championships competitor
- Andrew Smith (field hockey) (born 1978), Australian field hockey player
- Andrew Smith (footballer, born 1879) (1879–1960), Scottish footballer with West Bromwich Albion and Bristol Rovers, among other clubs
- Andrew Smith (footballer, born 1989), English footballer with Accrington Stanley
- Andrew Smith (rugby) (born 1985), Australian rugby union player
- Andrew Smith (sprinter) (born 1964), Jamaican sprinter
- Andrew Michael Smith (born 1967), English cricketer
- Andrew W. Smith (died 1959), American football player, coach and homeopathic physician
- Andrew Smith (canoeist), British slalom canoeist
- Andrew Smith (Australian footballer) (born 1960), Australian rules footballer
- Andrew Smith (golfer), Canadian amateur golfer
- Andy Smith (American football) (1883–1926), American college football coach
- Andy Smith (darts player) (born 1967), darts player who competes in Professional Darts Corporation events
- Andy Smith (footballer, born 1890) (1890–1968), English football player
- Andy Smith (footballer, born 1968), Scottish football player (Airdrie, Dunfermline)
- Andy Smith (footballer, born 1980), Northern Ireland international football player
- Andy Smith (hurler) (born 1983), Irish hurler
- Andy Smith (rugby league) (born 1984), English rugby league player
- Andy Smith (speedway rider) (born 1966), former Speedway Grand Prix rider
- Andrew Smith (gymnast) (born 1991), Irish artistic gymnast
Government and military
- Andrew Smith (British politician) (born 1951), English Labour Party politician
- Andrew Jackson Smith (1815–1897), American Civil War army general
- Andrew Jackson Smith (Medal of Honor) (1843–1932), American Civil War soldier
- Andrew Juxon-Smith (1933–1996), politician and military official in Sierra Leone
- Andrew Smith (military officer), Royal Canadian Navy officer
- Andrew Smith (Canadian politician), member of the Legislative Assembly of Manitoba
Other fields
- Andrew A. Smith (born 1959), American young adult fiction writer
- Andrew Smith (author) (born 1961), non-fiction writer
- Andrew Smith (composer) (born 1970), British-Norwegian classical conductor, organist and composer
- Andrew Smith (zoologist) (1797–1872), Scottish zoologist
- Andrew Lawrenceson Smith (1620–1694), Scottish painter
- Andrew Phillip Smith (born 1966), Welsh writer
- Andrew Hayden-Smith (born 1983), English actor, presenter; formerly known as Andrew Smith
- Andrew Smith Hallidie (1836–1900), American rail transport designer and promoter, born as Andrew Smith
- Andy Smith (entrepreneur) (born 1968), American author and entrepreneur
- Andrew Smith (1836–1894), one of the Smith Brothers who were makers of cough drops
- Andrew Smith (judge) (born 1947), judge of the High Court of England and Wales
- Andrew Smith (bishop) (born 1944), suffragan bishop of the Episcopal Diocese of Connecticut
- Andrew Reynolds Smith (born 1966), British businessman